Objective: To investigate the expression and clinical significance of serum soluble endothelial protein C receptor (sEPCR) in patients with rheumatoid arthritis (RA). Methods: From August 2022 to May 2023,80 RA patients were admitted to Department of Rheumatology and Immunology,the First Affiliated Hospital of Baotou Medical College,along with 80 healthy individuals as the control (HC) group during the same period. Basic information of all participants,as well as laboratory examination indicators and Disease Activity Score in 28 joints (DAS28) scores of RA patients,were recorded and organized. The levels of serum sEPCR in both groups were measured using enzyme-linked immunosorbent assay (ELISA). The serum sEPCR levels were compared between HC and RA groups,as well as the levels among different disease activities. Spearman analysis was employed to explore the correlation between serum sEPCR levels and clinical and laboratory indicators in RA patients. ROC analysis was performed to assess its clinical diagnostic value. Results: The serum sEPCR levels were significantly increased in the RA group compared to the HC group (P＜0.000 1). Correlation analysis showed that sEPCR levels were positively correlated with age,erythrocyte sedimentation rate (ESR),C-reactive protein (CRP),and DAS28 score (P＜0.001). ROC analysis revealed an area under the curve (AUC) of 0.901 7,with a serum sEPCR level less than 0.693 2 ng/mL as the diagnostic cutoff value,demonstrating a sensitivity of 81.01% and specificity of 88.31%. Conclusion: Serum sEPCR levels are closely related to the disease activity of RA,and have a certain diagnostic value for RA.
ZHANG Peiyao
,
HUO Yinping
,
GAO Yajie
,
LIU Huiyang
,
BAI Li
,
WANG Yongfu
. Clinical correlation between serum sEPCR level and rheumatoid arthritis[J]. Journal of Baotou Medical College, 2025
, 41(3)
: 59
-64
.
DOI: 10.16833/j.cnki.jbmc.2025.03.011
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