Objective: To observe the effect of quercetin on esophageal mucosal barrier function in rats with gastroesophageal reflux and explore its mechanism. Methods: Forty SD rats were randomly divided into blank control group, model group, quercetin administration group and positive control group. In addition to the blank control group, the rest of the rat model of reflux esophagitis was established. The quercetin administration group was given quercetin 50 mg/kg, the positive control group was given omeprazole 1.52 mg/kg, hydrotalcite 56.89 mg/kg, and domperidone 1.14 mg/kg. The blank control group was given an equal volume of normal saline once a day for 14 consecutive days. After the last administration, the rats were anesthetized and the blood was taken from the abdominal aorta, and the esophageal tissue samples were sacrificed. Then the pathological staining of esophageal tissue samples was performed, and the contents of TNF-α and IL-6 were detected by LISA, and the expression of IL-6 and TNF-α was detected by B. Results: Compared with the blank control group, the esophageal mucosa of the model group had obvious pathological changes, such as white and rough mucosa, defect, squamous epithelial hyperplasia, etc. Compared with the model group, the gastroesophageal histopathological changes in the quercetin treatment group were reduced. Compared with the blank control group, the contents of IL-6 and TNF-α in the model group were significantly increased (P＜0.05). Compared with the model group, the contents of IL-6 and TNF-α in the administration group and the positive control group were significantly decreased (P＜0.05). WB results showed that compared with the model group, the expression of TNF-α and IL-6 in the administration group and the positive control group was significantly decreased (P＜0.01). Conclusion: Quercetin may play a protective role by reducing inflammatory response and promoting gastroesophageal mucosal repair.
ZHANG Juan
,
ZHANG Ming
,
HE Jingbo
. Study on the regulatory effect of quercetin on inflammatory factors in rats with reflux esophagitis[J]. Journal of Baotou Medical College, 2025
, 41(3)
: 54
-58
.
DOI: 10.16833/j.cnki.jbmc.2025.03.010
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