Objective: To investigate the mechanism of Banxia Baizhu Tianma Decoction (BBTD) on ischemic stroke. Methods: A total of 90 SD rats (245-280 g) were selected to prepare MCAO animal model by referring to Zea-longa's modified suture method. The cerebral infarction area of MCAO model animals was detected by TTC staining. The protein expression level of IL-6 in ischemic penumbra of ischemic brain tissue was detected by WB method, and the mRNA expression level of IL-6 in ischemic penumbra of ischemic brain tissue was detected by RT-PCR method. Results: Compared with the sham operation group, the percentage of cerebral infarction area in the model group increased, and the difference was statistically significant (P＜0.05). Compared with the model group, the percentage of cerebral infarction area in BBTD and nimodipine treatment groups decreased to varying degrees, and the difference was statistically significant (P＜0.05). Compared with the sham operation group, the protein expression level of inflammatory factor IL-6 in the model group was significantly increased, and the difference was statistically significant (P＜0.05). Compared with the model group, the protein expression level of inflammatory factor IL-6 in the BBTD and nimodipine treatment groups was decreased to varying degrees, and the difference was statistically significant (P＜0.05). Compared with the sham operation group, the mRNA expression level of inflammatory factor IL-6 in the model group was significantly increased, and the difference was statistically significant (P＜0.05). Compared with the model group, the mRNA expression level of inflammatory factor IL-6 in BBTD and nimodipine treatment groups was decreased to varying degrees, and the difference was statistically significant (P＜0.05). Conclusion: Classic Banxia Baizhu Tianma Decoction can effectively alleviate ischemic brain injury in stroke events, which may be related to the inflammatory response mediated by IL-6.
LI Jiaren
,
ZHAO Shuran
,
LIU Jiayu
,
WU Wei
,
CHEN Xiao
,
HAO Xiaoqiong
,
SHI Ruili
. Study on the mechanism of action of the classic compound Banxia Baizhu Tianma Decoction on ischemic stroke[J]. Journal of Baotou Medical College, 2025
, 41(3)
: 24
-29
.
DOI: 10.16833/j.cnki.jbmc.2025.03.005
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