Objective: To study the correlation between the occurrence, development of hypertension in elderly patients complicated with cerebral infarction and peripheral blood miRNA-31 levels. Methods: From July 2022 to April 2023, 100 patients with simple hypertension (Group A) and 100 hypertension patients with complicated with cerebral infarction (Group B) were collected from the First Affiliated Hospital of Baotou Medical College as the experimental group, and 100 normal individuals who underwent physical examination at the same hospital (Group C) were selected as the control group. Patients in the cerebral infarction group (Group B) was divided into mild stroke group, moderate stroke group, and severe stroke group based on the degree of neurological dysfunction. Expression levels of miRNA-31 in peripheral blood of each group were detected using qPCR fluorescence quantification method. Results: The risk factors analyzing results showed that the blood lipid levels in the Group B were higher than those in the group A and the control group, and the differences were statistically significant (P＜0.01). The levels of peripheral blood miRNA-31 in the group B (mild, moderate, and severe stroke groups) were higher than those in the group A and control group [(3.81±0.865), (5.006±1.745), (8.217±1.755), (1.52±0.792), and (1.275±1.034)] (P＜0.05). The severity of cerebral infarction represented by the patient's ADL score was positively correlated with miRNA-31(r=0.878, P＜0.01), while miRNA-31 was positively correlated with the severity of cerebral infarction represented by the NHISS score (r=0.657, P＜0.01). The area under the curve of miRNA-31 in peripheral blood for diagnosing hypertension complicated with cerebral infarction is 0.979, with sensitivity and specificity values of 95.3% and 91.7%, respectively. Conclusion: The miRNA-31 level in elderly hypertensive patients complicated with cerebral infarction is higher than that in other groups, and can be used as a reference indicator for evaluating the risk of cerebral infarction in hypertensive patients.
DU Qiaming
,
DANG Liansheng
. Correlation between miRNA-31 and hypertension in elderly patients complicated with cerebral infarction and its predictive value[J]. Journal of Baotou Medical College, 2025
, 41(1)
: 86
-90
.
DOI: 10.16833/j.cnki.jbmc.2025.01.016
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