Objective: To analyze the relationship between neutrophil/lymphocyte ratio (NLR) and postoperative recurrence and metastasis in patients with advanced gastric cancer after radical gastrectomy. Methods: A total of 96 patients with advanced gastric cancer who underwent radical gastrectomy in the hospital from December 2016 to February 2019 were selected as the case group, and 65 healthy volunteers who came to the hospital for physical examination during the same period were selected as the healthy control group. The NLR levels of the two groups were compared. After 3 years of follow-up, the patients were divided into recurrence and metastasis group and non-recurrence and metastasis group according to whether there was recurrence and metastasis after operation at the last follow-up. The NLR level and related factors that may affect postoperative recurrence and metastasis were compared between the two groups. Logistic regression analysis was used to analyze the risk factors of postoperative recurrence and metastasis in patients with advanced gastric cancer. The receiver operating characteristic curve (ROC) was drawn to analyze the predictive value ofNLR for postoperative recurrence and metastasis in patients with advanced gastric cancer after radical gastrectomy. Results: The level of NLR in the case group was significantly different from that in the healthy control group (P＜0.05). Univariate analysis showed that TNM stage, tumor differentiation, depth of invasion, postoperative radiotherapy and chemotherapy, tumor diameter and NLR were significantly different between the two groups (P＜0.05). Multivariate analysis showed that TNM stage, depth of invasion, tumor diameter and NLR were the influencing factors of postoperative recurrence and metastasis in patients with advanced gastric cancer after radical gastrectomy (P＜0.05). ROC curve showed that the area under the curve of NLR in predicting postoperative recurrence and metastasis in patients with advanced gastric cancer after radical gastrectomy was 0.732. Conclusion: NLR is highly expressed in patients with advanced gastric cancer after radical gastrectomy. As a factor affecting postoperative recurrence and metastasis, NLR has certain clinical value in predicting postoperative recurrence and metastasis.
MENG Baocang
. Relationship between neutrophil/lymphocyte ratio and recurrence and metastasis after radical surgery for advanced gastric cancer[J]. Journal of Baotou Medical College, 2024
, 40(12)
: 77
-81
.
DOI: 10.16833/j.cnki.jbmc.2024.12.015
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