Objective: To investigate the risk factors associated with the prognosis of pulmonary hypertension associated with left heart disease (PH-LHD). Methods: From September 2020 to February 2021,132 patients with PH-LHD who met the inclusion and exclusion criteria in the Department of Cardiology, the First Affiliated Hospital of Baotou Medical College and the Second Affiliated Hospital of Baotou Medical College were included and followed up for an average of 12 months. Demographic data, biochemical indicators, echocardiographic parameters, and clinical events of all patients were collected. The main event was all-cause mortality. Univariate and multivariate COX proportional hazard regression models were used to screen the risk factors related to the prognosis of patients with left heart-related pulmonary hypertension. The relationship between PASP and the prognosis of patients with pulmonary hypertension was analyzed by Kaplan-Meier survival curve. Results: A total of 132 patients with PH-LHD were included, of which 109 (82.6%) patients completed the follow-up, with an average follow-up of 12 (8.1, 15.9) months, and a total of 31 patients died. Univariate COX regression analysis showed that age, pulmonary artery systolic pressure (PASP), left ventricular end-diastolic diameter (LVDD), right ventricular diameter (RVD), pulmonary artery flow rate, hemoglobin, high-sensitivity C-reactive protein (hs-CRP), aspartate aminotransferase (AST), blood glucose (GLU), PT, INR, triglyceride (TG), and free thyroxine (FT4) were risk factors for prognosis in patients with PH-LHD (all P＜0.05). Multivariate COX regression analysis showed that age, LVDD, RVD, Hb, hs-CRP, PASP (P＜0.01) and GLU (P＜0.05) were independent risk factors for the prognosis of PH-LHD patients. Kaplan-Meier survival curve showed that the incidence of all-cause death in patients with PASP >52 mmHg was higher than that in patients with PASP ≤52 mmHg (P＜0.01). Conclusion: Age, LVDD, RVD, Hb, hs-CRP, GLU and PASP are independent risk factors for all-cause mortality in patients with pulmonary hypertension associated with left heart disease. The incidence of all-cause mortality in patients with PASP >52 mmHg is higher than that in patients with PASP ≤52 mmHg.
WANG Yanjin
,
YAN Xulong
,
YUE Jianwei
,
YANG Xiaomin
,
WANG Luyao
. Analysis of prognostic factors in patients with left heart disease associated pulmonary hypertension[J]. Journal of Baotou Medical College, 2024
, 40(12)
: 62
-67
.
DOI: 10.16833/j.cnki.jbmc.2024.12.012
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