Objective: To investigate the effects of intravenous general anesthesia combined with epidural block and ultrasound-guided transversus abdominis plane block on postoperative analgesia and early rehabilitation in patients undergoing laparoscopic ovarian cystectomy. Methods: One hundred patients undergoing laparoscopic ovarian cystectomy, ASA grade I or II, were randomly divided into transversus abdominis plane block analgesia group (group A, n=50) and epidural block analgesia group (group B, n=50). The operation time of block analgesia, the residence time in the anesthesia recovery room, the VAS scores before and 2 h, 4 h, 8 h, 12 h and 24 h after operation, the use of rescue analgesics, the recovery time of diet after operation, the time of first getting out of bed after operation, the occurrence of headache, vomiting, nausea and hypotension after operation, and the patient satisfaction were compared between the two groups. Results: The operation time of block analgesia in group A was shorter than that in group B (P＜0.05). There was no significant difference in residence time in anesthesia recovery room between the two groups (P＞0.05). The VAS scores of group B at 2 h, 8 h, 12 h and 24 h after operation were lower than those of group A (P＜0.05). The usage rate of rescue analgesics in group B was lower than that in group A (P＜0.05). There was no significant difference in postoperative diet recovery time and the first time to get out of bed after operation between the two groups (P＞0.05). Except for hypotension, there was no significant difference in the incidence of postoperative headache, nausea and vomiting between the two groups (P＞0.05). The patient satisfaction of group B was higher than that of group A (P＜0.05). Conclusion: For patients undergoing laparoscopic ovarian cystectomy under general anesthesia, the analgesic effect and analgesic time of combined epidural block are better than those of combined transversus abdominis plane block ; however, both have little effect on early postoperative rehabilitation.