Changes of plasma metabolites and metabolic pathways in patients with left ventricular hypertrophy

  • GAO Ting ,
  • YANG Xiaomin ,
  • CAO Rong ,
  • YUE Jianwei
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  • 1. 2020 Graduate Students of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014040,China;
    2. Department of Cardiology, the Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Institute of Hypertension, Inner Mongolia Autonomous Region;
    3. General Practice Department of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

Received date: 2023-07-20

  Online published: 2024-12-24

Abstract

Objective: To investigate the metabolic changes and possible metabolic pathways of hypertension with or without left ventricular hypertrophy (LVH) and healthy people. Methods: Thirty patients with hypertension (HTN) (HTN group), 30 patients with hypertension and LVH (LVH group) and 30 healthy volunteers (control group) were recruited. The metabolic profiles of plasma samples were obtained by non-targeted metabolomics. Results: A total of 1141 metabolites were detected, of which 43 were significantly different only in LVH group and control group, such as leucine, adenine, magnolol and so on. Leucine and adenine were up-regulated in LVH patients. According to the analysis of KEGG pathway, a total of 22 differential metabolites were involved in the metabolic pathway of LVH. Compared with HTN group, linoleic acid metabolism and α-linolenic acid (α-linolenicacid,ALA) metabolic pathway were down-regulated in LVH group. Conclusion: Compared with healthy subjects, the metabolic spectrum of patients with LVH is significantly different, indicating that myocardial fatty acids may be protective factors of LVH, leucine and adenine may be risk factors of LVH, and LVH can be improved by α-linolenic acid metabolic pathway.

Cite this article

GAO Ting , YANG Xiaomin , CAO Rong , YUE Jianwei . Changes of plasma metabolites and metabolic pathways in patients with left ventricular hypertrophy[J]. Journal of Baotou Medical College, 2024 , 40(12) : 37 -42 . DOI: 10.16833/j.cnki.jbmc.2024.12.007

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