Objective: To analyze the core drug pairs and their molecular biological mechanisms for the treatment of hepatitis B cirrhosis based on data mining and network pharmacology. Methods: Retrieve all the literatures related to the application of traditional Chinese medicine in the treatment of hepatitis B cirrhosis from January 2000 to December 2022 in China National Knowledge Infrastructure, Wanfang Database and VIP Science and Technology Journal, and study the medication rules of the prescriptions that meet the standards. The commonly used core drug pairs were subjected to pharmacological analysis, and the active components, main targets, and action pathways were predicted. Finally, molecular docking technology was used to simulate and verify on the computer. Results: A total of 275 prescriptions for the treatment of hepatitis B cirrhosis were screened. The analysis showed that TCM for the treatment of hepatitis B cirrhosis included 13 kinds of drugs such as Huangqi and Danshen. The core combination mode was 28 groups. Quercetin,Luteolin,Kaempferoland other ingredients were found as the main components of core prescription drugs for the treatment of hepatitis B cirrhosis,involving core targets such as serine/threonine protein kinase 1 (AKT1), tumor necrosis factor (TNF), tumor protein p53 (TP53), interleukin-6 (IL-6), vascular endothelial growth factor A (VEGFA), Caspase-3 (CASP3) and phosphatidylinositol-3-kinase/protein kinase (PI3K/Akt), TNF, interleukin-17 (Interleukin-17). Conclusion: The treatment principle of hepatitis B cirrhosis is to strengthen the body and relieve masses. "Huangqi-Danshen" can play a role in regulating cell growth, proliferation, survival and inflammatory reaction by interfering with PI3K-Akt, TNF, IL-17 and other signal pathways, so as to delay the progression of liver cirrhosis in hepatitis B.
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