Effect of CCN1 on APRIL/BAFF expression in esophageal cancer cells

  • XING Lingling ,
  • LIU Lin ,
  • JIANG Zhenyu ,
  • CHAI Jianyuan ,
  • WU Jinbao
Expand
  • 1. Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014040, China;
    2. Inner Mongolia Digestive Disease Research Institute, the Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology

Received date: 2024-05-10

  Online published: 2024-12-24

Abstract

Objective: To investigate the role of CCN1 protein in a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF) in esophageal cancer. Methods: CCN1 was overexpressed in KYSE150 and OE-19 cell lines by plasmid transfection technique. The transfection effect was verified by Western blot, and the expression of APRIL and BAFF was detected. Results: APRIL/BAFF was highly expressed after overexpression of CCN1 in KYSE150 cells (P<0.05), and APRIL/BAFF was lowly expressed after overexpression of CCN1 in OE19 cells (P<0.05). Conclusion: CCN1 activates APRIL/BAFF in esophageal squamous cell carcinoma cell line KYSE150 and inhibits APRIL/BAFF in esophageal adenocarcinoma cell line OE19.

Cite this article

XING Lingling , LIU Lin , JIANG Zhenyu , CHAI Jianyuan , WU Jinbao . Effect of CCN1 on APRIL/BAFF expression in esophageal cancer cells[J]. Journal of Baotou Medical College, 2024 , 40(12) : 13 -17 . DOI: 10.16833/j.cnki.jbmc.2024.12.003

References

[1] Morgan E,Soerjomataram I,Rumgay H, et al.The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality in 2020 and projections to 2040: new estimates from GLOBOCAN 2020[J].Gastroenterology,2022,163(3):649-658.e2.
[2] Chang Z, Dang T, Meng X, et al. The role of CCN1 in esophageal adenocarcinoma: what we have learned from the lab[J].Cancer Control, 2022, 29:10732748221074734.
[3] Ullah MA, Mackay F. The BAFF-APRIL system in cancer[J].Cancers (Basel),2023,15(6):1791.
[4] Mulazzani M, Huber M, Borchard S, et al. APRIL and BAFF: novel biomarkers for central nervous system lymphoma[J].J Hematol Oncol,2019,12(1):102.
[5] Alturaiki W. The roles of B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) in allergic asthma[J].Immunol Lett,2020,225:25-30.
[6] Tian S, Chen K, Xiao J, et al. APRIL and BAFF play a key role in differentiating vitreoretinal lymphoma from uveitis[J].Clin Chim Acta,2022,535:1-6.
[7] Lee L, Lim WC, Galas-Filipowicz D, et al. Limited efficacy of APRIL CAR in patients with multiple myeloma indicate challenges in the use of natural ligands for CAR T-cell therapy [J].J Immunother Cancer,2023,11(6):e006699.
[8] Chan CC, Harley ITW, Pfluger PT, et al. A BAFF/APRIL axis regulates obesogenic diet-driven weight gain[J].Nat Commun,2021,12(1):2911.
Outlines

/