Objective: To investigate the role of CCN1 protein in a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF) in esophageal cancer. Methods: CCN1 was overexpressed in KYSE150 and OE-19 cell lines by plasmid transfection technique. The transfection effect was verified by Western blot, and the expression of APRIL and BAFF was detected. Results: APRIL/BAFF was highly expressed after overexpression of CCN1 in KYSE150 cells (P＜0.05), and APRIL/BAFF was lowly expressed after overexpression of CCN1 in OE19 cells (P＜0.05). Conclusion: CCN1 activates APRIL/BAFF in esophageal squamous cell carcinoma cell line KYSE150 and inhibits APRIL/BAFF in esophageal adenocarcinoma cell line OE19.
XING Lingling
,
LIU Lin
,
JIANG Zhenyu
,
CHAI Jianyuan
,
WU Jinbao
. Effect of CCN1 on APRIL/BAFF expression in esophageal cancer cells[J]. Journal of Baotou Medical College, 2024
, 40(12)
: 13
-17
.
DOI: 10.16833/j.cnki.jbmc.2024.12.003
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