Objective: To investigate the clinical value of CD26 and CLDN1 in the prevention and treatment of papillary thyroid carcinoma (PTC). Methods: Pathological tissue section specimens of 48 surgical patients with PTC admitted to Baotou Cancer Hospital from December 2021 to December 2022 were selected, with tumor tissues as the experimental group and adjacent tissues as the control group. The expression levels of CD26 and CLDN1 in the two groups were measured by immunohistochemistry. SPSS 27.0 was used to analyze the relationship between CD26, CLDN1 and clinicopathology in PTC patients. The correlation between the positive rates of each group was tested by Spearman correlation analysis (α＝0.05). Results: The positive expression rates of CD26 and CLDN1 in tumor tissues were 85.42% and 83.33%, respectively, which were higher than 27.08% and 20.83% in adjacent tissues, and the differences were statistically significant (P＜0.05). There was no significant difference in the positive expression rate of CD26 and CLDN1 protein in different PTC patients with different age, gender, maximum tumor diameter, unilateral, bilateral thyroid gland tumors, and invasion of the capsule (all P＞0.05). CD26 and CLDN1 were correlated with lymph node metastasis(P＜0.05). There was a significant positive correlation between the expression of CD26 and CLDN1 in PTC tissues (rs＝0.294, P＜0.05). Conclusion: CD26 and CLDN1 play an important role in the occurrence and development of PTC. Combined detection of CD26 and CLDN1 is helpful to the diagnosis and treatment of PTC.
ZHANG Zuoyu
,
FU Fushan
,
YANG Xiaonan
,
WANG Zhanlong
. Correlation study of CD26、CLDN1 and papillary thyroid cancer[J]. Journal of Baotou Medical College, 2024
, 40(11)
: 46
-49
.
DOI: 10.16833/j.cnki.jbmc.2024.11.010
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