Objective: To explore the dynamic changes of metabolic activity after multiple intakes of alcohol, and to analyze the induction and gender differences of metabolic enzyme activity. Methods: The end-expiratory alcohol detection method of rats was established by breath alcohol detectors, and the breath alcohol concentration of rats after intragastric administration of alcohol was detected. The time-varying changes of blood alcohol concentration of rats after alcohol intake were dynamically measured, and the pharmacokinetic parameters were calculated to evaluate cytochrome P450 2E1(CYP2E1)metabolic activity and gender differences in rats. Results: With the increase of alcohol intake, the metabolic activity of CYP2E1 showed an induced trend (P＜0.05). The activity of alcohol metabolism in female rats was stronger than that in male rats (P＜0.05). Conclusion: Alcohol metabolism and induction have sexual dimorphism.
CAO Yingying
,
HAO Peipei
,
WANG Jiayu
,
REN Bida
,
ZHANG Kun
,
XUE Yongzhi
. Dynamic changes and sexual dimorphism of alcohol metabolic activity[J]. Journal of Baotou Medical College, 2024
, 40(11)
: 1
-4
.
DOI: 10.16833/j.cnki.jbmc.2024.11.001
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