Objective: To investigate the prevalence of metabolic syndrome (MS) and Helicobacter pylori (Hp) infection, and to analyze the relationship between MS and Hp infection, uric acid (UA). Methods: A total of 305 patients with HP infection and UA were selected from the Zhangzhou Affiliated Hospital of Fujian Medical University from January 2022 to September 2022, they were divided into the MS Group and non-MS Group, HP (+) group and HP (-) group. BP and blood glucose were compared between groups. Binary logistic regression model was used to analyze the risk factors of MS and the relationship between Hp infection and age and sex. Results: The incidence of MS and Hp infection was 15.41% and 44.92% respectively. There were significant differences in age, male ratio, Hp infection rate, UA, BMI, TG, blood glucose, BP and HDL-C between the MS Group and the non-MS Group (P＜0.05). There were significant differences in age, MS ratio, UA, BMI, overweight, TG, hypertriglyceridemia, BP, hypertension, HDL-C and low HDL-C between Hp (+) group and Hp (-) group (P＜0.05). Age was an independent risk factor for Hp infection. Hp infection, male gender, HDL-C, blood glucose, DBP and BMI were independent risk factors for MS. Conclusion: The incidence of MS in male is higher than that in female. The relationship between Hp infection and sex is not obvious, but the infection rate increases with higher age. Hp infection and male are independent risk factors for MS, while UA was not.
WANG Zhen
,
CHEN Heqing
. Correlation analysis of metabolic syndrome with Helicobacter pylori infection and uric acid[J]. Journal of Baotou Medical College, 2024
, 40(10)
: 46
-50
.
DOI: 10.16833/j.cnki.jbmc.2024.10.010
[1] 郭海健, 念馨, 梁友芳, 等. 基于多中心横断面调查的中国人群代谢综合征的流行情况及危险因素[J]. 中华疾病控制杂志, 2019, 23(7): 796-801.
[2] Nagy P, Johansson S, Molloy-Bland M. Systematic review of time trends in the prevalence of Helicobacter pylori infection in China and the USA[J]. Gut Pathogens, 2016, 8(1): 8.
[3] 第六次全国幽门螺杆菌感染处理共识报告(非根除治疗部分)[J]. 胃肠病学, 2022, 27(5): 289-304.
[4] 曹燕飞, 李小玲, 王彦斐, 等. 基于年龄分层视角的幽门螺杆菌感染影响因素研究[J]. 浙江医学, 2023, 45(2): 140-144.
[5] 范可心, 苏成铭, 刘超, 等. 北京地区不同职业人群幽门螺杆菌感染现状分析[J]. 中国医药, 2022, 17(8): 1193-1196.
[6] 陈琼, 李灵辉. 2608例健康体检人群幽门螺杆菌检查结果分析[J]. 中国卫生标准管理, 2022, 13(24): 45-49.
[7] 王龙, 邵荣青, 许梦情, 等. 健康体检人群幽门螺杆菌感染情况分析[J]. 感染、炎症、修复, 2022, 23(3): 138-141.
[8] Lim SH, Kim N, Kwon JW, et al. Positive association between Helicobacter pylori infection and metabolic syndrome in a korean population: a multicenter nationwide study[J]. Dig Dis Sci, 2019, 64(8): 2219-2230.
[9] 李刚, 曹素艳, 张野, 等. 幽门螺杆菌感染与腹型肥胖的相关性研究[J]. 中华全科医师杂志, 2022, 21(4): 361-366.
[10] Baradaran A, Dehghanbanadaki H, Naderpour S, et al. The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case-control studies[J]. Clin Diabetes Endocrinol, 2021, 7(1): 15.
[11] 郝晶晶, 孙菁, 燕文敬. 幽门螺杆菌感染与代谢综合征的相关性[J]. 中华医院感染学杂志, 2023, 33(6): 856-859.
[12] Zhou JL, Wang XY, Liu KR, et al. Association between Helicobacter pylori infection and the risk of type 2 diabetes mellitus based on a middle-aged and elderly Chinese population[J]. Endocr J, 2022, 69(7): 839-846.
[13] Wan ZC, Hu L, Hu M, et al. Helicobacter pylori infection and prevalence of high blood pressure among Chinese adults[J]. J Hum Hypertens, 2018, 32(2): 158-164.
[14] 吕岩红, 张志勉. 2809名体检人群中高血压与幽门螺杆菌感染的关联性[J]. 山东大学学报(医学版), 2022, 60(2): 43-47.
[15] Yue LM, Zhang RG, Chen SY, et al. Relationship between Helicobacter pylori and incident hypertension as well as blood pressure: a systematic review and meta-analysis[J]. Dig Dis, 2023, 41(1): 124-137.
[16] 李鲁, 刘涛, 邹媛, 等. 4408例体检者幽门螺杆菌感染与血脂异常的相关性分析[J]. 新疆医科大学学报, 2022, 45(3): 351-355.
[17] Nie GQ, Wan JJ, Jiang L, et al. Correlation analysis between uric acid and metabolic syndrome in the chinese elderly population: a cross-sectional study[J]. Int J Endocrinol, 2023: 8080578.
[18] Zhong DR, Liu DC, Guo YT, et al. Association of the serum uric acid to creatinine ratio with metabolic syndrome in the middle age and older population in China[J]. Front Endocrinol (Lausanne), 2022, 13: 1060442.
