Objective: To investigate the correlation between neutrophil, lymphocyte, platelet and their ratio and obstructive sleep apnea hypopnea syndrome (OSAHS) with hypertension. Methods: A total of 107 patients with OSAHS complicated with hypertension, 85 patients with simple OSAHS and 45 healthy subjects in Jiangmen Central Hospital were selected as the research objects. The hematological indexes of the three groups were detected and compared, including neutrophils, lymphocytes, platelets, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). The relationship between OSAHS complicated with hypertension and hematological indexes was analyzed. Results: The neutrophil count in the control group, the simple OSAHS group and OSAHS combined with hypertension group was (4.18±1.04)×10⁹/L, (4.47±1.02)×10⁹/L, and (5.15±1.44)×10⁹/L, respectively. The neutrophil count in the OSAHS combined with hypertension group was higher than that in control group and simple OSAHS group (P＜0.05), but there was no significant difference between simple OSAHS group and control group (P＞0.05). The NLR level in the control group, the simple OSAHS group and OSAHS combined with hypertension group was (1.94±0.48), (2.24±0.68), (2.51±0.733),respectively. The NLR level in the OSAHS combined with hypertension group and the simple OSAHS group was higher than that in the control group, and that in the OSAHS combined with hypertension was higher than that in the simple OSAHS group, the differences was statistically significant (P＜0.05). There was statistical difference in NLR level between mild hypertension group and moderate hypertension group (P＜0.05), but there was no statistical difference between moderate hypertension group and severe hypertension group (P＞0.05). There was no significant difference in lymphocytes, platelets and PLR among the three groups (P＞0.05). Conclusion: NLR is significantly increased in OSAHS patients with hypertension, and NLR may be positively correlated with the severity of hypertension.