Objective: To investigate the effect of glycated hemoglobin control level on gonadal hormone, body mass index, blood lipid and visceral fat area in middle-aged and elderly male patients with type 2 diabetes mellitus, and to analyze the related factors affecting testosterone. Methods: A total of 90 middle-aged and elderly male patients with type 2 diabetes mellitus were selected and divided into good blood glucose control group (30 patients, glycosylated hemoglobin＜7%), poor blood glucose control group (30 patients, glycosylated hemoglobin 7%～9%) and bad blood glucose control group (30 patients, glycosylated hemoglobin ＞9%), the age, body mass index, blood lipid, visceral fat area and gonadal hormone of the patients were collected, and the data of the three groups were statistically analyzed. According to testosterone greater than the median (≤4.08 ng/mL) and less than or equa to the median (＜4.08 ng/mL), they were divided into two groups, and the body mass index, visceral fat area, glycosylated hemoglobin, blood lipids and other data between the two groups were statistically analyzed. Results: The level of glycosylated hemoglobin was negatively correlated with high density lipoprotein and testosterone (P＜0.05), and positively correlated with triglyceride, total cholesterol, low density lipoprotein, body mass index, visceral fat area and estradiol (P＜0.05), but not with follicle stimulating hormone, luteinizing hormone and prolactin (P＞0.05). Testosterone was negatively correlated with body mass index, visceral fat area, glycosylated hemoglobin, triglyceride, total cholesterol and low density lipoprotein (P＜0.05), and positively correlated with high density lipoprotein (P＜0.05). Logistic regression analysis showed that glycosylated hemoglobin level, visceral fat area, body mass index and dyslipidemia were risk factors for testosterone reduction. Conclusion: Good blood glucose control can effectively reduce the decrease of testosterone in men, and can effectively promote the body's lipid metabolism; higher testosterone levels also play a positive role in blood glucose and lipid metabolism. Glycosylated hemoglobin, visceral fat area, body mass index, dyslipidemia are risk factors for testosterone reduction.
LI Min
,
SUN Jian
,
ZHANG Lifei
,
ZHU Hongwei
,
ZHAO Yuanyuan
,
CAO Qing
,
TIAN Yanshuang
,
GUO Xiaoyong
. Analysis of correlation between glycosylated hemoglobin control level and gonadal hormone in middle-aged and elderly male patients with type 2 diabetes mellitus[J]. Journal of Baotou Medical College, 2024
, 40(8)
: 55
-59
.
DOI: 10.16833/j.cnki.jbmc.2024.08.011
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