Objective: To observe the clinical effect and safety of total glucoside of paeony combined with bicyclol in the treatment of mild autoimmnue hepatitis. Methods: A total of 56 patients with mild AIH admitted from April 2020 to April 2023 were randomly divided into treatment group and control group, with 28 patients in each group. The treatment group was given total glucosides of paeony (0.6 g/time, 3 times/d) combined with bicyclol (50 mg/time, 3 times/d) oral treatment, while the control group was only given bicyclol (50 mg/time, 3 times/d) oral treatment. The liver inflammation indexes, immunological related indexes and liver fibrosis indexes of the two groups were measured at baseline, 12 weeks and 24 weeks of treatment, and the drug-related adverse reactions were recorded. Results: After 24 weeks, the total effective rates of the treatment group and the control group were 89.29% and 60.71%, respectively, and the difference was statistically significant (P=0.037). There were significant differences in ALT, AST, CD4+T(%), CD8+T(%), total globulin and IgG levels between the two groups (P＜0.001), but there was no significant difference in ALP and liver stiffness measurement (LSM) between the two groups. Compared with the control group, the levels of ALT, AST, CD8+T(%), total globulin and IgG in the treatment group decreased, and the level of CD4+T(%) increased after 24 weeks. Compared with the baseline, the LSM values of the two groups decreased after 24 weeks. There was no significant difference in the incidence of adverse reactions between the two groups (P=1.0). Conclusion: Total glucosides of paeony combined with bicyclol can better improve the level of liver inflammation in patients with mild AIH, regulate the immune status of the body, control the progression of liver fibrosis and do not increase the incidence of adverse drug reactions.
SUN Chao
,
WU Chengsheng
,
ZHANG Caicai
,
ZHANG Yurui
. Clinical observation of total glucosides of paeony combined with bicyclol in the treatment of mild autoimmune hepatitis[J]. Journal of Baotou Medical College, 2024
, 40(8)
: 49
-54
.
DOI: 10.16833/j.cnki.jbmc.2024.08.010
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