Objective: To study the association between single nucleotide polymorphism (SNP) in YAP gene and the risk of colorectal cancer. Methods: YAP rs11225163 was genotyped by Taqman technique in 390 colorectal cancer cases and 413 controls. The odds ratio (OR) and its 95% confidence interval(CI) were calculated by unconditional logistic regression to evaluate the relationship between rs11225163 and the risk of colorectal cancer, rectal cancer and colon cancer under five genetic models: co-dominant, dominant, recessive, overdominant and Log-additive. Results: No associations were found between SNP rs11225163 and the risk of colorectal cancer, rectal cancer and colon cancer under 5 genetic models. Conclusion: YAP gene SNP rs11225163 may not play a major role in the development of colorectal cancer, rectal cancer and colon cancer.
GAO Fang
,
WEI Xingru
,
LI Yingze
,
DONG Wenjie
,
CHEN Yaru
,
WANG Qiaoqiao
,
JIA Yanbin
. Association between YAP gene SNP rs11225163 and colorectal cancer[J]. Journal of Baotou Medical College, 2024
, 40(8)
: 7
-10
.
DOI: 10.16833/j.cnki.jbmc.2024.08.002
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