Objective: To explore the role of lipoyltransferase (LIPT1) in the development and immune infiltration of breast cancer by bioinformatics. Methods: TCGA, GEPIA, HPA, UALCAN, Kaplan-Meier, TIMER 2.0 and other databases were used to explore the differential expression, function and related mechanism of LIPT1 in breast cancer, and to analyze the effect of LIPT1 on the immune infiltration of invasive breast cancer. Results: The expression of LIPT1 was associated with invasive breast cancer, and PPI network analysis showed that LIPT1 was associated with ACSM1, DBT, DLAT, DLT, DLST, GCSH, LIAS, LIPT2, PDHB, and PDHX; the expression of LIPT1 was associated with immune cell infiltration in invasive breast cancer. Conclusion: Bioinformatics predicts that LIPT1 expression is down-regulated in invasive breast cancer and is associated with tumor immune cell infiltration.
ZHANG Zhaojun
,
SUN Jieke
,
LI Jianseng
,
SHI Yurong
. Expression and immune infiltration prediction of copper death related gene LIPT1 in breast cancer[J]. Journal of Baotou Medical College, 2024
, 40(8)
: 1
-6
.
DOI: 10.16833/j.cnki.jbmc.2024.08.001
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