Objective:To systematically evaluate the risk factors of hyperuricemia (HUA) in middle-aged and elderly people in China. Methods:The Embase,Web of Science,PubMed,the Cochrane Library,Chinese National Knowledge Infrastructure (CNKI),Wangfang Data,Chinese Biomedical Literature Database (CBM),and VIP database were selected to collect literaturse on risk factors of HUA in middle-aged and elderly people in China. The retrieval time limitation was defined from the establishment of the database until March 2022. RevMan 5.3 and Stata 14.0 software were used for data analysis. Results:A total of 20 studies were included,including 72 020 cases of HUA patient. Meta-analysis results showed that hypertension (OR=1.43,95%CI: 1.26-1.62),age ≥45 (OR=1.11,95%CI: 1.07-1.15),alcohol consumption (OR=1.47,95%CI: 1.31-1.65),high body mass index (BMI) (OR=1.06,95%CI: 1.02-1.19),high triglyceride (TG) (OR=1.81,95%CI: 1.58-2.07),renal insufficiency (OR=2.88,95%CI: 1.76~4.73),high cholesterol (TC) (OR=1.21,95%CI: 1.09~1.33),high serum creatinine (OR=1.69,95%CI: 1.53~1.85),central obesity (OR=1.52,95%CI: 1.30-1.79) and high urea nitrogen (OR=1.53,95%CI: 1.23-1.90) were risk factors for HUA in middle-aged and elderly people in China. High density lipoprotein (HDL-C) (OR=0.50,95%CI:0.36~0.70) and hyperglycemia (OR=0.75,95%CI: 0.66-0.86) were protective factors to HUA in middle-aged and elderly people in China. Conclusion:Hypertension,age ≥45 years,alcohol consumption,high BMI,high TG,renal insufficiency,high TC,high serum creatinine,central obesity and high urea nitrogen are the risk factors for HUA in middle-aged and elderly people in China. Meanwhile,high blood glucose and HDL-C are the protective factors to HUA.
[1] Vargas-Santos AB, Neogi T. Management of gout and hyperuricemia in CKD[J]. Am J Kidney Dis, 2017, 70(3): 422-439.
[2] Skoczyńska M, Chowaniec M, Szymczak A, et al. Pathophysiology of hyperuricemia and its clinical significance-a narrative review[J]. Reumatologia, 2020, 58(5): 312-323.
[3] Lv S, Liu W, Zhou YJ, et al. Hyperuricemia and severity of coronary artery disease: an observational study in adults 35 years of age and younger with acute coronary syndrome[J]. Cardiol J, 2019, 26(3): 275-282.
[4] Lippi G, Montagnana M, Franchini M, et al. The paradoxical relationship between serum uric acid and cardiovascular disease[J]. Clin Chim Acta, 2008, 392(1-2): 1-7.
[5] Capuano V, Marchese F, Capuano R, et al. Hyperuricemia as an independent risk factor for major cardiovascular events: a 10-year cohort study from Southern Italy[J]. J J Cardiovasc Med (Hagerstown), 2017, 18(3): 159-164.
[6] 李静. 高尿酸血症的流行病学研究[J]. 中国心血管杂志, 2016, 21(2): 83-86.
[7] 李林, 朱小霞, 戴宇翔, 等. 中国高尿酸血症相关疾病诊疗多学科专家共识[J]. 中华内科杂志, 2017, 56(3): 235-248.
[8] 陈丽云, 朱景新, 余燕飞, 等. 上海某社区老年人高尿酸血症患病率及影响因素分析[J]. 上海医药, 2020, 41(20): 47-49.
[9] 陈剑锋, 马斌. 上海市高东社区老年体检人群高尿酸血症发病及其影响因素分析[J]. 中国公共卫生, 2022, 38(4): 414-419.
[10] 邬付骏, 邬美花. 上海农村某社区中老年人高尿酸血症检出率及影响因素分析[J]. 上海医药, 2021, 42(10): 45-47, 51.
[11] 薛冰, 丁东新, 沈琪, 等. 老年人高尿酸血症的患病特征调查及相关因素分析[J]. 中国老年学杂志, 2008, (2): 157-158.
[12] 胡梦妍, 刘锦波, 周春华. 桂林市老年人群高尿酸血症的患病情况及危险因素分析[J]. 广西医学, 2017, 39(1): 81-83, 91.
[13] 王嘉楠, 谈文峰, 孙国民, 等. 某社区中老年居民高尿酸血症患病情况及影响因素分析[J]. 解放军医学杂志, 2020, 45(2): 212-218.
[14] 渠井泉, 祝洁, 李青, 等. 上海远郊某镇老年人群高尿酸症患病率及影响因素调查研究[J]. 陕西医学杂志, 2020, 49(3): 375-377, 385.
[15] 江会运, 王峥, 陈聪. 上海市金山卫社区老年体检人群高尿酸血症检出状况及影响因素分析[J]. 社区医学杂志, 2020, 18(18): 1267-1270.
[16] 林细明, 邹蓉, 李协, 等. 增城市荔城农村老年高尿酸血症现况及危险因素分析[J]. 中国医药导报, 2014, 11(11): 101-104.
[17] 李薇. 社区60岁以上老年人群高尿酸血症患病调查及影响因素分析[J]. 慢性病学杂志, 2022, 23(1): 97-100.
[18] 李晚冉, 林锦春, 王箭, 等. 罗湖区中老年男性高尿酸血症危险因素回顾性分析[J]. 现代医院, 2021, 21(7): 1073-1075.
[19] 李岩, 孙景波. 社区老年人高尿酸血症患病率及危险因素调查研究[J]. 重庆医学, 2017, 46(12): 1666-1668.
[20] 朱冰坡, 范利, 蔺士杰, 等. 益阳地区老年体检人群高尿酸血症患病率及相关危险因素分析[J]. 中华老年心脑血管病杂志, 2018, 20(2): 164-167.
[21] 张林, 蔡秋妮. 老年人高尿酸血症发病率调查及影响因素分析[J]. 中华老年医学杂志, 2021, 40(6): 784-787.
[22] 屈炯堂, 刘本坚, 梁美玲. 老年退休人员高尿酸血症的患病率及影响因素分析[J]. 中华老年心脑血管病杂志, 2013, 15(11): 1142-1145.
[23] 卢逸烨, 余佩毅, 宋锐, 等. 上海某社区老年人血尿酸发病率调查及影响因素分析[J]. 上海医药, 2015, 36(22): 39-42.
[24] 刘胜峰, 赖华娟, 何纳. 上海市社区老年人高尿酸血症发病率及其影响因素分析[J]. 中国公共卫生, 2017, 33(10): 1445-1449.
[25] 于丽, 徐智晔, 马俐华, 等. 老年人高尿酸血症的相关危险因素研究[J]. 西南国防医药, 2014, 24(1): 51-53.
[26] 严慧艳, 王敬丽, 陈晟, 等. 上海市大场社区老年高尿酸血症的流行病学调查[J]. 中国初级卫生保健, 2022, 36(1): 66-69.
[27] 陈乃君, 周嘉强. 绍兴地区某老年体检人群高尿酸血症危险因素的Logistic回归分析[J]. 中国老年学杂志, 2016, 36(17): 4225-4226.
[28] Yokokawa H, Fukuda H, Suzuki A, et al. Association between serum uric acid levels/hyperuricemia and hypertension among 85,286 Japanese workers[J]. J Clin Hypertens (Greenwich), 2016, 18(1): 53-59.
[29] Buzas R, Ivan VS, Gheorghe-Fronea OF, et al. Arterial hypertension and serum uric acid in elderly- SEPHAR III study[J]. Arq Bras Cardiol, 2021, 117(2): 378-384.
[30] 刘靖. 重视高血压患者高尿酸血症的筛查与管理[J]. 中华高血压杂志, 2021, 29(8): 701-702.
[31] Song PG, Wang H, Xia W, et al. Prevalence and correlates of hyperuricemia in the middle-aged and older adults in China[J]. Sci Rep, 2018, 8: 4314.
[32] Makinouchi T, Sakata K, Oishi M, et al. Benchmark dose of alcohol consumption for development of hyperuricemia in Japanese male workers: an 8-year cohort study[J]. Alcohol, 2016, 56: 9-14.
[33] 付佐娣, 赵子厚, 王连英, 等. 北京社区人群高尿酸血症患病率与肥胖关系的研究[J]. 中国糖尿病杂志, 2021, 29(1): 30-34.
[34] 宋康, 姚勇利, 魏兰, 等. 青海省汉族居民高尿酸血症的患病情况分析[J]. 现代预防医学, 2018, 45(22): 4094-4096, 4161.
[35] Kang D. Hyperuricemia and progression of chronic kidney disease: role of phenotype transition of renal tubular and endothelial cells[J]. Contrib Nephrol, 2018, 192: 48-55.
[36] Borghi C, Agabiti-Rosei E, Johnson RJ, et al. Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease[J]. Eur J Intern Med, 2020, 80: 1-11.
[37] 高璐, 信中, 袁明霞, 等. 不同性别老年人群高尿酸血症与代谢综合征的相关性分析[J]. 中华老年心脑血管病杂志, 2017, 19(5): 461-465.
[38] Zhang Y, Zhang MM, Yu XW, et al. Association of hypertension and hypertriglyceridemia on incident hyperuricemia: an 8-year prospective cohort study[J]. J Transl Med, 2020, 18: 409.
[39] 许敏锐, 强德仁, 周义红, 等. 常州农村社区35~70岁人群代谢综合征及其组分与高尿酸血症的相关性研究[J]. 现代预防医学, 2020, 47(9): 1607-1611.
[40] 李明珍, 聂秀玲, 孙丽荣. 高尿酸血症与糖代谢异常的关系[J]. 国际内分泌代谢杂志, 2016, 36(4): 217-219.
[41] 王洪莎, 郭蔚莹. 高尿酸血症与高血糖、高血压及肥胖的关系[J]. 中国老年学杂志, 2016, 36(22): 5729-5732.
