Objective: To detect the expression level of circular RNA-BBS9 in acute cerebral infarction (ACI), and to explore its possibility as a potential biomarker for early diagnosis of ACI. Methods: A total of 34 patients with ACI admitted from January to December 2021 were randomly selected as the case group, and 41 patients without ACI were selected as the control group. The general data and blood samples were collected for bioinformatics analysis. Circ RNA with the greatest difference was selected as the target gene, and the correlation between the general data, the expression level of the target gene and the occurrence of ACI in the two groups was analyzed. ROC curve was used to analyze the value of target gene in the diagnosis of ACI. Results: The proportion of male, age, history of hypertension, history of coronary heart disease, history of smoking, history of drinking and blood pressure in the case group were higher than those in the control group (P＜0.05). The CircRNA with the greatest difference was Circ-BBS9. The expression level of Circ-BBS9 in the case group was lower than that in the control group (P＜0.05). Sex, age, history of hypertension, history of coronary heart disease, history of smoking, history of drinking, blood pressure and Circ-BBS9 expression were all related to the occurrence of ACI (P＜0.05). The expression of Circ-BBS9 was negatively correlated with the occurrence of ACI, while other factors were positively correlated with the occurrence of ACI (P＜0.05). Circ-BBS9 had the value of diagnosing ACI. Conclusion: Circ-BBS9 is a protective factor of acute cerebral infarction, and the expression level of Circ-BBS9 is an independent factor affecting the occurrence of ACI. Detection of Circ-BBS9 in peripheral blood has potential value in predicting the pathogenesis of ACI.
ZHANG Haiyan
,
YUAN Rui
,
ZHOU Wenhui
,
LIU Dan
,
ZHANG Guangwei
. Expression level and clinical significance of Circ-BBS9 in peripheral blood of patients with acute cerebral infarction[J]. Journal of Baotou Medical College, 2024
, 40(6)
: 43
-48
.
DOI: 10.16833/j.cnki.jbmc.2024.06.008
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