Objective: To investigate the influencing factors and roles of serum Cys C in microangiopathy of type 2 diabetes mellitus.Methods: A total of 830 patients with T2DM admitted from September 2020 to June 2022 were selected as the research objects, and the patients were divided into observation group (type 2 diabetic microangiopathy group) and control group (simple type 2 diabetes group) according to whether they had microangiopathy. The basic data and biochemical indexes of the two groups were compared. Results: The prevalence of hypertension, duration of diabetes and age in the observation group were higher than those in the control group (P＜0.05). The levels of glycosylated hemoglobin (HbA1c), fasting blood glucose (FPG), serum creatinine (Scr), uric acid (UA), serum cystatin C (Cys C), low density lipoprotein (LDL), triglyceride (TG), serum total cholesterol (TC), apolipoprotein A (APOA) and apolipoprotein B (APOB) in the observation group were higher than those in the control group, and the level of high density lipoprotein (HDL) was lower than that in the control group (P＜0.05). Binary logistic regression analysis showed that hypertension, course of disease, HbA1c, FPG, Cys C, HDL and APOA were the influencing factors of T2DM microangiopathy. The receiver operating curve (ROC) results showed that Cys C could be used as a potential diagnostic indicator for T2DM microvascular disease (AUC=0.707, P=0.000). Conclusion: HbA1c, FPG, HDL, APOA, hypertension, duration of diabetes, Cys C and other factors are independent influencing factors of T2DM microangiopathy, and serum Cys C can be used as a potential diagnostic indicator. The focus of T2DM microangiopathy management is not only to control blood glucose, but also to find prevention and treatment targets from a new perspective, providing new ideas for the prevention and treatment of T2DM microangiopathy.
WANG Haiyan
,
ZHANG Yonghong
. Influencing factors and roles of serum Cys C in microangiopathy of type 2 diabetes mellitus[J]. Journal of Baotou Medical College, 2024
, 40(6)
: 25
-29
.
DOI: 10.16833/j.cnki.jbmc.2024.06.005
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