Objective: To investigate the relationship between the proportion of CD19+CD27+IgD+B cells in peripheral blood and disease activity in patients with thyroid-associated ophthalmopathy (TAO). Methods: Flow cytometry was used to detect the proportion of CD19+CD27+IgD+B cells in TAO patients and healthy control groups. The difference in the proportion of CD19+CD27+IgD+B cells between TAO patients and healthy control groups was analyzed. The correlation between the proportion of CD19+CD27+IgD+B cells and activity was also analyzed. Results: The proportion of CD19+CD27+IgD+B cells in TAO patients was significantly lower than that in healthy controls (P＜0.05). The proportion of CD19+CD27+IgD+B cells in active TAO patients was significantly lower than in inactive TAO patients. The proportion of CD19+CD27+IgD+B cells was significantly negatively correlated with the CAS score of TAO patients (r=-0.7128, P＜0.001). Conclusion: The proportion of CD19+CD27+IgD+B cells in TAO patients is decreased, which is negatively correlated with disease activity.
FENG Yuelan
,
LIU Zhiying
,
WANG Yuanyuan
,
ZHANG Wei
. The correlational research on CD19+CD27+IgD+B cells and disease activity in patients with thyroid-associated ophthalmopathy[J]. Journal of Baotou Medical College, 2024
, 40(4)
: 33
-37
.
DOI: 10.16833/j.cnki.jbmc.2024.04.006
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