Objective: To study the expression level, prognosis and correlation with immune cell infiltration of BUB1B in pancreatic adenocarcinoma ( PAAD ) by online database and bioinformatics. Methods: The expression of BUB1B in various cancers was analyzed by GEPIA database. The correlation between the expression of BUB1B and the prognosis of PAAD patients was searched by GEPIA and Kaplan-Meier Plotter database. Then, the protein interaction network of BUB1B co-expressed genes was constructed by using String database, and its GO biological function and KEGG signaling pathway were analyzed by using David database. Finally, the TIMER database was used to analyze the correlation between the expression of BUB1B gene and immune cell infiltrating cells. Results: The expression level of BUB1B in PADD tissues was higher than that in normal tissues (P＜0.01). The high transcription level of BUB1B was closely related to gender, age, race, obesity, drinking habits, chronic pancreatitis, lymph node metastasis and cancer stage (P＜0.05). The expression level of BUB1B mRNA was associated with prognosis and immune cell infiltration (P＜0.05). Conclusion: BUB1B is highly expressed in PADD, which is related to prognosis and immune infiltration, and can be used as a potential marker for diagnosis, prognosis and drug treatment of pancreatic cancer.
JIA Lulu
,
FENG Xiaoyan
,
TIAN Yuting
,
REN Xiaowei
,
ZOU Lina
,
Ma Hongkun
,
RONG Shengzhong
. Correlation analysis of BUB1B with occurrence, immune infiltration and prognosis of pancreatic adenocarcinoma[J]. Journal of Baotou Medical College, 2024
, 40(4)
: 1
-7
.
DOI: 10.16833/j.cnki.jbmc.2024.04.001
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