Objective: To explore the effects of psychological intervention and group activities on the psychological state and treatment compliance of patients with multi-drug resistant tuberculosis. Methods: A total of 200 patients were randomly divided into the control group and intervention group with 100 cases in each group. The control group received routine health education and general routine nursing. Psychological intervention, group activities and other forms of intervention were used in the intervention group. The self-rating Symptom Scale (SCL-90) was used to evaluate the psychological status of patients, and the medication compliance scale was used to evaluate the medication compliance. Results: The total mean score of SCL-90 in the intervention group was lower than that in the control group (t=2.877, P=0.004). Items of SCL-90 including somatization, obsessive symptoms, interpersonal sensitivity, depression, paranoia, psychosis, sleep and diet, the scores of the above items were lower in the intervention group than those in the conventional group (P＜0.05). The total mean score of treatment compliance in the intervention group was higher than that in the control group (t=-2.740, P=0.007). "Is it difficult for you to take anti-tuberculosis medicine for a long time?", "How often have you forgot taking your medication? ", Have you ever forgot taking your TB medicine in the past two weeks? ", the scores of the above 3 items in the intervention group were all higher than those in the control group (P＜ 0.05). Conclusion: Psychological intervention and group activities can alleviate the adverse psychological state of MDR-TB patients, improve the treatment compliance, and enhance the recovery of patients.