Objective: To study the causal relationship between vitamin D and hyperemesis gravidarum by two-sample Mendelian randomization. Methods: Based on the IEU OpenGWAS project website, the GWAS data set of vitamin D with the largest sample size and the GWAS data set of hyperemesis gravidarum were searched. The SNPs strongly associated with vitamin D were selected from the ieu-b-4808 library, and P＜5×10-8 with a linkage disequilibrium coefficient of 0.001 and a region width of 10 000 kb were set. SNPs associated with hyperemesis gravidarum were selected from finn-b-O15_EXCESS_VOMIT_PREG. The combined data set included 174 SNPs as instrumental variables. The association between vitamin D and hyperemesis gravidarum was analyzed by four regression models: random effect inverse variance weighting (IVW), MR-Egger, weighted median, and weighted model. Results: The MR-Egger regression intercept was 0.005, and the corresponding P value was 0.513, suggesting that the SNPs had no gene pleiotropy. IVW regression results showed that OR(95%CIs) was 0.478(0.303-0.753), P value was 0.001; the results of MR-Egger, weighted median and weighted model were similar to those of IVW. The Cochran's Q values of IVW and MR-Egger regression were 143.733(P=0.893) and 143.303(P=0.888), respectively, suggesting that there was no heterogeneity between SNPs. Conclusion: Vitamin D is one of the protective factors of hyperemesis gravidarum in pregnancy.
CHENG Hong
. Causal association between vitamin D and hyperemesis gravidarum: a two-sample Mendelian randomization study[J]. Journal of Baotou Medical College, 2024
, 40(2)
: 78
-82
.
DOI: 10.16833/j.cnki.jbmc.2024.02.014
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