Objective: To explore the possibility of miR-296-5p and miR-107 as diagnostic markers of acute myocardial infarction by detecting the expression levels of miR-296-5p and miR-107 in plasma of patients with acute myocardial infarction and healthy people and the time trend in patients with acute myocardial infarction. Methods: From November 2021 to March 2022, 60 patients with acute myocardial infarction (myocardial infarction group) and 60 age-matched healthy patients (control group) who underwent physical examination in the physical examination center of Baotou Central Hospital were selected as the research objects. The myocardial infarction group was divided into reperfusion group (30 patients) and conventional drug treatment group (30 patients) according to different intervention measures. Fluorescence quantitative real-time PCR (RT-qPCR) was used to detect the relative expression of plasma miR-296-5p and miR-107 at admission and at different time points after intervention. Results: Compared with the control group, the expression levels of plasma miR-296-5p and miR-107 in patients with acute myocardial infarction were significantly increased (P＜0.05). After 48 hours of reperfusion therapy or conventional drug treatment, the relative expression levels of plasma miR-296-5p and miR-107 were significantly decreased (P＜0.05). After 7 days of reperfusion therapy or conventional drug treatment, the relative expression of plasma miR-296-5p and miR-107 decreased to normal levels (P＜0.05). Conclusion: The relative expression levels of miR-296-5p and miR-107 in plasma of patients with acute myocardial infarction are significantly higher than those of normal individuals, and shows a downward trend after intervention measures, which has predictive value for the diagnosis of acute myocardial infarction.
ZHAO Qiang
,
ZHAO Ruiping
. Predictive value of plasma MicroRNA-296-5P and MicroRNA-107 expression levels in the diagnosis of acute myocardial infarction[J]. Journal of Baotou Medical College, 2023
, 39(12)
: 36
-39
.
DOI: 10.16833/j.cnki.jbmc.2023.12.007
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