Objective: To analyze the correlation between serum Betatrophin, interleukin-1β (IL-1β), vascular endothelial growth factor (VEGF) and diabetic retinopathy (DR). Methods: Patients with type 2 diabetes mellitus (T2DM) who were hospitalized from March 2021 to June 2022 were selected and divided into three groups: non-diabetic retinopathy (NDR) group, non-proliferative diabetic retinopathy (NPDR) group and proliferative diabetic retinopathy (PDR) group. In addition, 37 patients without diabetes mellitus (NC) were selected as the control group. The levels of serum Betatrophin, IL-1β and VEGF were detected. The correlation between Betatrophin, IL-1β, VEGF and diabetic retinopathy was analyzed by comparison between groups. Logistic regression and adjustment model methods were used to explore the influencing factors of diabetic retinopathy, and the diagnostic value of the three factors for DR and DR staging was evaluated by drawing the receiver operating curve (ROC). Results: Compared with the NDR group, the serum Betatrophin, IL-1β and VEGF in the NPDR group and the PDR group were increased, and the differences among the three groups were statistically significant (P＜0.05). Betatrophin, IL-1β and VEGF were positively correlated in T2DM patients (P＜0.05). Logistic regression analysis showed that Betatrophin, IL-1β and VEGF were risk factors for diabetic retinopathy. When predicting DR patients, the area under the ROC curve of serum Betatrophin was 0.89, the area under the ROC curve of IL-1β was 0.71, and the area under the ROC curve of VEGF was 0.84; When predicting PDR patients, the area under the ROC curve of serum IL-1βwas 0.83, the area under the ROC curve of Betatrophin was 0.76, and the area under the ROC curve of VEGF was 0.72. Conclusion: Betatrophin, IL-1β and VEGF are involved in the development of DR, and Betatrophin has a predictive role in DR and its severity.
JIAO Chenxu
,
LIN Xiaohui
. Study on the correlation between betatrophin, interleukin 1β, vascular endothelial growth factor and diabetic retinopathy[J]. Journal of Baotou Medical College, 2023
, 39(12)
: 20
-25
.
DOI: 10.16833/j.cnki.jbmc.2023.12.004
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