Objective: To investigate the antidepressive effect of Qingxin Chenxiang Bawei Powder and its effect on monoamine neurotransmitters.Methods: Kunming male mice were randomly divided into the blank control group (distilled water), positive-drug group (fluoxetine hydrochloride 0.02 g/kg) and Mongolian medicine Qingxin Chenxiang Bawei Powder groups [the high-dose (27 g/kg) group, medium-dose (9 g/kg)group and low-dose (3 g/kg) group].Intragastric administration were performed on all experimental mice.Mice tail suspension test (TST) and forced swimming test (FST) were used to evaluate the antidepressive effect of the drug 7 days after intragastric administration.After FST behavioral experiment, the contents of 5-HT, DA and NE in plasma and hippocampus were determined by enzyme-linked immunosorbent assay (ELISA).Results: Compared with the blank control group, medium-dose and low-dose groups of Mongolian medicine could significantly shorten the immobility time in mice FST, and the difference was statistically significant (P＜0.05).The immobility time in mice TST was significantly shortened in the low-dose group, and the difference was statistically significant(P＜0.05).The plasma DA level was significantly increased in the low-dose group, and the difference was statistically significant (P＜0.05).The levels of 5-HT, DA and NE in the hippocampus of mice in the low-dose, medium-dose and high-dose groups were significantly increased, and the difference was statistically significant (P＜0.05).Conclusion: Qingxin Chenxiang Bawei Powder have certain antidepressive effect on mice, which may be related to its regulation effect on monoamine neurotransmitter content.
WANG Yanfang
,
SONG Kuan
,
SONG Zhaohe
,
ZHANG Hongli
,
MA Yong
,
WEI Simeng
. Effects of Mongolian Medicine Qingxin Chenxiang Bawei Powder on behavior and monoamine neurotransmitter in mice with acute depression[J]. Journal of Baotou Medical College, 2023
, 39(11)
: 92
-96
.
DOI: 10.16833/j.cnki.jbmc.2023.11.018
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