Objective: To study the effect of individualized nursing care based on risk assessment on the prognosis of cesarean section, the incidence of postoperative venous thrombosis and postpartum rehabilitation. Methods: A total of 80 parturient women who underwent cesarean section in the Third People's Hospital of Bengbu from January 2021 to April 2022 were selected and randomly divided into the routine group and the study group by random number table method. Routine intervention was performed on parturient women in the routine group, and personalized nursing care based on risk assessment was performed on parturient women in the study group. The prognosis, incidence of postoperative venous thrombosis and postpartum rehabilitation were compared between the two groups. Results: The extubation time, feeding time, lactation time and defecation time of the study group were (10.39±3.56) h, (10.39±2.16) h, (23.41±3.69) h and (26.31±5.16) h, respectively, which were significantly lower than those of the routine group (P＜0.05). The D-2 polymers, platelet levels and prothrombin time in the study group were significantly lower than those in the routine group (P＜0.05). The VAS scores at 6h, 12h and 24h of the study group were (3.71±1.03), (3.76±0.91) and (3.22±0.83) respectively, which were significantly lower than those of the routine group (P＜ 0.05). Within 1 week after delivery, lochia excretion in the study group was (80.21±15.43) mL, which was significantly lower than that in the routine group (P＜0.05), and the distance between the fundus and the umbilicus in the study group was (2.27±0.35) cm, which was significantly higher than that in the routinel group (P＜0.05). Conclusion: Individualized nursing based on risk assessment for cesarean section can effectively improve the prognosis of patients, reduce the incidence of postoperative venous thrombosis and pain degree, and help to accelerate recovery of woman after cesarean section, which is worthy of promotion.