Objective: To explore the prognostic significance of D-dimer, routine coagulation tests and platelet parameters in pregnant women. Methods: A total of 454 cases of pregnant women who came to Guangdong Tongjiang Hospital for examination and delivery from January 2020 to June 2021 were selected as the normal pregnancy group (96 cases in the first trimester, 138 cases in the second trimester, 114 cases in the third trimester, and 106 cases in the parturient period), another 60 cases of pregnancy with other diseases such as gestation combining with diabetes or hypertension were selected as the other-disease-combining group, and 45 cases of obstetric accidents were collected as the obstetric accident group. In addition, 167 cases of non-pregnant women in childbearing age who came to our hospital for health examination were selected as the healthy control group. The D-D level and coagulation tests including activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (FIB), and thrombin time (TT) were compared among the four groups. The platelet parameters including platelet count (PLT), mean platelet volume (MPV), and platelet volume distribution width (PDW) were also compared among the four groups. Results: The levels of D-D and FIB in the normal pregnancy group were significantly lower than those in the other-disease-combining group and the obstetric accident group (P＜0.05). PT level in the normal pregnancy group was significantly higher than that in the other-disease-combining group and the obstetric accident group (P＜0.05). The PLT, MPV and PDW levels in the normal pregnancy group were significantly higher than those in the other-disease-combining group and the obstetric accident group (P＜0.05). Conclusion: Four indexes of blood coagulation, D-D and platelet parameters can effectively monitor the state of blood coagulation of pregnant women before delivery, which is of great significance in mastering the coagulation condition, improving the pregnancy outcome and preventing maternal thrombosis or postpartum hemorrhage, it is worthy of popularization and clinical promotion.
ZHONG Jieyi
. Prognostic significance of D-dimer, routine coagulation tests and platelet parameters in pregnant women[J]. Journal of Baotou Medical College, 2023
, 39(11)
: 55
-58
.
DOI: 10.16833/j.cnki.jbmc.2023.11.011
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