Objective: To investigate the correlation between primary intussusception and food allergen-specific IgE, food-specific IgG and vasoactive intestinal peptide. Methods: A total of 35 children with intussusception admitted to the Fourth Hospital of Baotou from October 2021 to May 2022 were selected into the experimental group, and 35 children with no intestinal diseases at the same period were selected into the control group. The levels of 7 food allergen-specific IgE antibodies, food-specific IgG antibodies and serum vasoactive intestinal peptide of children between the two groups were compared. Results: The total positive rate of food allergen-specific IgE in children of the experimental group was 40.00 % and 28.57 % in the control group, and the differences in positive rate and total positive rate of food allergen-specific IgE of the two groups were not statistically significant (P＞0.05). The total positive rate of food-specific IgG was 88.57 % in the children of the experimental group and 62.86 % in the control group, and the difference was statistically significant (P＜0.05), but the difference in the positive rate of various types of food-specific IgG in the two groups was not statistically significant (P＞0.05). The level of vasoactive intestinal set was lower in the experimental group than that in the control group, and the difference was statistically significant (P＜0.05). The difference in serum vasoactive intestinal peptide levels between food-specific IgG-positive and negative children was statistically significant (P＜0.05), and there was a negative correlation between food-specific IgG and vasoactive intestinal peptide (P＜0.05). Conclusions: No significant correlation was seen between food allergen-specific IgE and the occurrence of primary intussusception, while food-specific IgG was correlated with the occurrence of primary intussusception. The changed levels of vasoactive intestinal peptides in the serum of children with intussusception suggest that the level of vasoactive intestinal peptide is related to the occurrence of primary intussusception, and that food-specific IgG may affect intestinal function by regulating the levels of vasoactive intestinal peptides, which ultimately lead to the occurrence of primary intussusception.
WANG Jun
,
ZHANG Ruimin
,
WU Xiangming
,
MIAO Wei
,
ZHAO Yongxiang
. Correlation analysis of primary intussusception with food allergen-specific IgE, food-specific IgG and vasoactive intestinal peptide[J]. Journal of Baotou Medical College, 2023
, 39(11)
: 37
-41
.
DOI: 10.16833/j.cnki.jbmc.2023.11.007
[1] Wallace A, Friedheim A, Parsh B. Intussusception: treatment and nursing considerations[J]. Nursing, 2022, 52(7): 12-13.
[2] Jiang J, Jiang BM, Parashar U, et al. Childhood intussusception: a literature review[J]. PLoS One, 2013, 8(7): e68482.
[3] 吕榜军, 郑文彬, 陈蔚恩. 肠套叠流行及病因研究进展[J]. 应用预防医学, 2020, 26(1): 85-88.
[4] Aydin E, Beşer OF, Ozek E, et al. Is there a causal relationship between intussusception and food allergy[J]. Children, 2017, 4(10): 89.
[5] 胡天一, 陶枫. 儿童过敏性疾病血清过敏原特异性IgE检测分析的临床意义[J]. 天津医科大学学报, 2022, 28(2): 169-172, 204.
[6] 卢山, 万极硕, 苏玉, 等. 北京地区食物特异性IgG抗体检测分析的研究[J]. 中华预防医学杂志, 2021, 55(2): 253-257.
[7] Killoran KE, Miller AD, Uray KS, et al. Role of innate immunity and altered intestinal motility in LPS- and MnCl2-induced intestinal intussusception in mice[J]. Am J Physiol Gastrointest Liver Physiol, 2014, 306(5): G445-G453.
[8] 万成亮, 海波, 白强, 等. 小儿肠套叠经腹腔镜下空气灌肠辅助复位与开腹手术复位的临床疗效比较[J]. 临床外科杂志, 2019, 27(7): 608-609.
[9] Turnbull JL, Adams HN, Gorard DA. Review article: the diagnosis and management of food allergy and food intolerances[J]. Aliment Pharmacol Ther, 2015, 41(1): 3-25.
[10] Savage J, Johns CB. Food allergy: epidemiology and natural history[J]. Immunol Allergy Clin North Am, 2015, 35(1): 45-59.
[11] Manuyakorn W, Tanpowpong P. Cow milk protein allergy and other common food allergies and intolerances[J]. Paediatr Int Child Health, 2019, 39(1): 32-40.
[12] 王桂立, 冯琳琳. 健康体检人群食物不耐受的流行现状及相关因素研究[J]. 解放军预防医学杂志, 2020, 38(6): 73-75.
[13] Zhou C, Chen LL, Lu RQ, et al. Alteration of intestinal microbiota composition in oral sensitized C3H/HeJ mice is associated with changes in dendritic cells and T cells in mesenteric lymph nodes[J]. Front Immunol, 2021, 12: 631494.
[14] Weiss GA, Hennet T. Mechanisms and consequences of intestinal dysbiosis[J]. Cell Mol Life Sci, 2017, 74(16): 2959-2977.
[15] Obata Y, Pachnis V. The effect of microbiota and the immune system on the development and organization of the enteric nervous system[J]. Gastroenterology, 2016, 151(5): 836-844.
[16] Langer I, Jeandriens J, Couvineau A, et al. Signal transduction by VIP and PACAP receptors[J]. Biomedicines, 2022, 10(2): 406.
