Objective: To investigate the correlation between primary intussusception and food allergen-specific IgE, food-specific IgG and vasoactive intestinal peptide. Methods: A total of 35 children with intussusception admitted to the Fourth Hospital of Baotou from October 2021 to May 2022 were selected into the experimental group, and 35 children with no intestinal diseases at the same period were selected into the control group. The levels of 7 food allergen-specific IgE antibodies, food-specific IgG antibodies and serum vasoactive intestinal peptide of children between the two groups were compared. Results: The total positive rate of food allergen-specific IgE in children of the experimental group was 40.00 % and 28.57 % in the control group, and the differences in positive rate and total positive rate of food allergen-specific IgE of the two groups were not statistically significant (P>0.05). The total positive rate of food-specific IgG was 88.57 % in the children of the experimental group and 62.86 % in the control group, and the difference was statistically significant (P<0.05), but the difference in the positive rate of various types of food-specific IgG in the two groups was not statistically significant (P>0.05). The level of vasoactive intestinal set was lower in the experimental group than that in the control group, and the difference was statistically significant (P<0.05). The difference in serum vasoactive intestinal peptide levels between food-specific IgG-positive and negative children was statistically significant (P<0.05), and there was a negative correlation between food-specific IgG and vasoactive intestinal peptide (P<0.05). Conclusions: No significant correlation was seen between food allergen-specific IgE and the occurrence of primary intussusception, while food-specific IgG was correlated with the occurrence of primary intussusception. The changed levels of vasoactive intestinal peptides in the serum of children with intussusception suggest that the level of vasoactive intestinal peptide is related to the occurrence of primary intussusception, and that food-specific IgG may affect intestinal function by regulating the levels of vasoactive intestinal peptides, which ultimately lead to the occurrence of primary intussusception.
WANG Jun
,
ZHANG Ruimin
,
WU Xiangming
,
MIAO Wei
,
ZHAO Yongxiang
. Correlation analysis of primary intussusception with food allergen-specific IgE, food-specific IgG and vasoactive intestinal peptide[J]. Journal of Baotou Medical College, 2023
, 39(11)
: 37
-41
.
DOI: 10.16833/j.cnki.jbmc.2023.11.007
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