Objective: To analyze the changes of serum co-stimulatory molecules B7-H3 level in peripheral serum of children with bronchial asthma (BA) and its correlation with the expression level of Th17 cytokine interleukin 17 (IL-17), and to explore the clinical significance of B7-H3 in children with BA. Methods: From June 2021 to December 2022, 72 children with BA were selected, including 32 children in acute attack (AA) group and 40 children in clinical remission (CR) group. At the same time, 33 children who received physical examination were randomly selected as healthy controls ( HC ) group. The expression levels of serum co-stimulatory factors B7-H3 and IL-17 in the three groups were detected. Results: There was no significant difference in the general data among the three groups (P＞0.05). There were significant differences in the expression levels of serum B7-H3 and IL-17 among the three groups (P＜0.05), while the levels of B7-H3 and IL-17 in BA group were higher than those in HC group, and those in AA group were higher than those in CR group (P＜0.05). There was a positive correlation between B7-H3 and IL-17 in peripheral serum of BA group (r=0.843, P＜0.05). According to the ROC curve drawn, the AUC of B7-H3 was 0.710, the optimal cut-off value was 20.67 ng/mL, the sensitivity and specificity for the diagnosis of BA were 70.80 % and 63.60 %, respectively, and the 95 % CI was (0.609-0.811). The AUC of IL-17 was 0.756, the optimal cut-off value was 47.40 pg/mL, the sensitivity and specificity were 72.20 % and 69.70 %, 95 %CI was (0.663,0.849). The AUC of the combined detection of the two factors was 0.754, the sensitivity and specificity were 80.60 % and 63.60 %, respectively, and the 95 %CI was (0.661-0.847). Conclusion: B7-H3 and IL-17 are involved in the occurrence and development of BA, and are also related to the severity of BA.They may be involved in the inflammatory response, airway remodeling and lung function injury of BA.B7-H3, IL-17 and their combined detection have good diagnostic efficacy for BA, and have certain clinical value for the identification and treatment guidance of BA in children.
CHEN Rui
,
JIA Chunmei
,
QU Yanjie
,
NING Lihua
,
WANG Wei
. Clinical significance of serum costimulatory factor B7-H3 level in children with bronchial asthma[J]. Journal of Baotou Medical College, 2023
, 39(10)
: 46
-50
.
DOI: 10.16833/j.cnki.jbmc.2023.10.010
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