Objective: To investigate the relationship between ubiquitin-specific protease 33 (USP33) and clinicopathological features and prognosis of patients with gastric cancer. Methods: The clinical and follow-up data of 60 patients with gastric cancer were collected. The expression level of USP33 in gastric cancer tissues and adjacent tissues was detected by immunohistochemical MaxVision method. The relationship between the expression level of USP33 in gastric cancer tissues and the clinicopathological features and prognosis of patients was analyzed. Results: Compared with adjacent tissues, the expression level of USP33 in gastric cancer tissues was decreased (P＜0.05). The expression level of USP33 in gastric cancer tissues was negatively correlated with TNM stage, lymph node metastasis and depth of invasion (P＜0.05). The prognosis of patients with high USP33 expression in gastric cancer tissues was better than that of patients with low USP33 expression (P＜0.05). Lower tumor differentiation, higher TNM stage, positive lymph node metastasis and low USP33 expression level were independent risk factors affecting the 1-year survival rate of gastric cancer patients (P＜0.05). Conclusion: USP33 is down-regulated in gastric cancer tissues, and its low expression is associated with poor prognosis, indicating that USP33 may be used as a molecular biomarker to predict the prognosis of gastric cancer patients and become a new target for future treatment of gastric cancer.
DONG Yongwei
,
GUO Qiang
,
MA Xingyue
,
CHEN Huiwen
,
LIU Jinyu
. Expression of ubiquitin-specific protease 33 and its relationship with clinicopathological features and prognosis of gastric cancer[J]. Journal of Baotou Medical College, 2023
, 39(10)
: 42
-45
.
DOI: 10.16833/j.cnki.jbmc.2023.10.009
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