Objective: To observe the effect of recombinant human bone morphogenetic protein-2 ( rhBMP-2 ) implantation in the treatment of osteoporotic intertrochanteric fracture. Methods: A total of 144 patients with osteoporotic intertrochanteric fractures admitted to the Second Department of Trauma, the First Affiliated Hospital of Baotou Medical College from 2020 to 2022 were selected and divided into two groups by random number table method, with 72 patients in each group. The control group was given simple fracture reduction (PFNa internal fixation). The observation group was combined with intraoperative local implantation of rhBMP-2 on the basis of the same surgical method in the control group. By analyzing the fracture healing time, fracture healing rate, pain digital score (NRS score), hip joint function score (Harris score), mortality, hospitalization time and other variable data of the two groups of patients during the follow-up period of 6 months, the complications, adverse reactions and treatment effects of the patients before and after operation were compared. Results: The fracture healing rate and hip joint function score in the observation group were higher than those in the control group (P＜0.05). The fracture healing time of the observation group was significantly shorter than that of the control group (P＜0.05).The incidence of complications and mortality in the observation group were lower than those in the control group (P＜0.05).There was no significant difference in pain numerical score (NRS score) and hospitalization time between the two groups (P＞0.05). Conclusion: Proximal femoral nail antirotation (PFNa internal fixation) is effective in the treatment of osteoporotic intertrochanteric fracture combined with local implantation of rhBMP-2, which is of great significance in promoting the recovery of hip joint function and reducing the occurrence of complications.
FENG Baihan
,
ZHANG Wenlong
. Effect of recombinant human bone morphogenetic protein-2 combined with proximal femoral nail internal fixation in the treatment of osteoporotic intertrochanteric fractures in the elderly[J]. Journal of Baotou Medical College, 2023
, 39(10)
: 23
-27
.
DOI: 10.16833/j.cnki.jbmc.2023.10.005
[1] 刘芳芳. 我国人口老龄化现状及医养结合模式研究[J].中国老年保健医学,2020,18(6):31-33.
[2] 中华医学会骨质疏松和骨矿盐疾病分会. 男性骨质疏松症诊疗指南[J].中华骨质疏松和骨矿盐疾病杂志,2020,13(5):381-395.
[3] 王欢,马琼,马保安. 我国高原地区骨质疏松的研究现况[J].医学信息,2020,33(23):34-37.
[4] 刘瑞奇. 骨质疏松骨折患者并发症的发生率、风险因素和经济负担研究[D].天津:天津大学,2017.
[5] 胡衍,陈晓,曹烈虎,等. 重视老年骨质疏松性骨折骨修复问题[J].中国骨与关节杂志,2019,8(3):161-164.
[6] 许昊,王培文. 老年骨质疏松患者髋部骨折发生及死亡危险因素分析[J].福建医药杂志,2021,43(1):136-139.
[7] 马远征,王以朋,刘强,等. 中国老年骨质疏松症诊疗指南(2018)[J].中国骨质疏松杂志,2018,24(12):1541-1567.
[8] 杨显红,齐新文,李松军. 骨髓间充质干细胞治疗骨质疏松性骨折的机制[J].医学综述,2020,26(7):1288-1292.
[9] 刘俊银,冯玮,谢映春,等. 骨再生修复中的骨形态发生蛋白信号通路:精准调节与治疗靶点[J].中国组织工程研究,2019,23(4):606-612.
[10] 陈锐棋,黄思聪. 骨形态发生蛋白2浓度对兔骨髓间充质干细胞生长的影响[J].医学理论与实践,2020,33(22):3693-3696.
[11] Wang H, Sun XC, Zhang D, et al. Active bone material containing modified recombinant human bone morphogenetic protein 2 induces bone regeneration in the alveolar process cleft in rabbits[J].Artif Organs, 2021,45(7):O207-O222.
[12] 翁汭,叶林强,黄学成,等. 重组人骨形态发生蛋白2联合自体骨行椎间植骨融合治疗胸腰椎结核[J].中国组织工程研究,2020,24(23):3609-3614.
[13] 章晓云,梁庆华,陈跃平,等. 手术联合口服中药膏方治疗胫骨骨折不愈合的疗效观察[J].中国骨与关节损伤杂志,2018,33(10):1086-1088.
[14] 陈启刚,胡永军,胡海,等. 锁定接骨板结合重组人骨形态发生蛋白骨修复材料治疗跟骨骨折的临床分析[J].安徽医药,2018,22(4):703-706.
[15] 李树源,周琦石,李悦,等. 重组人骨形态发生蛋白2、富血小板血浆联合植骨与单纯植骨修复骨缺损的比较[J].中国组织工程研究,2019,23(22):3463-3468.
[16] 祝俊雄,宋纯理. 骨质疏松及其骨折的局部药物治疗[J].中国骨质疏松杂志,2018,24(6):806-813.
[17] 许汉权,李彩华. 老年骨质疏松性粗隆间骨折的治疗[J].广东医学,2018,39(20):3051-3054.
[18] 施彦龙,李应福,谢兴文,等. BMP/Smads、OPG/RANK/RANKL信号通路与骨质疏松关系的研究进展[J].中国骨质疏松杂志,2020,26(4):600-604.
