Objective: To study the correlation between ultrasound detection of multi-site visceral fat and atherosclerosis, with the purpose to find more indicators that may affect atherosclerosis, so as to help clinicians evaluate cardiovascular and cerebrovascular diseases more accurately. Methods: From June 2021 to March 2022, 95 patients who were diagnosed with Carotid Atherosclerosis (CAS) in the Ultrasound Department of Yijishan Hospital, Anhui South Medical College, and 39 healthy volunteers were selected as the research objects. All research objects were grouped into the IMT ≤0.9mm group and the IMT >0.9mm group according to the intima-media thickness (IMT). Visceral fat parameters in multiple sites of the two groups were measured and compared. Results: Epicardial adipose tissue (EAT), subcutaneous fat thickness (SCFT), preperitoneal fat thickness (PPFT), visceral fat thickness (VFT), the difference in right perineal periphery fat thickness (PRPFT), VFT/SCFT, visceral adipose tissue (VAT) and left and right renal fat sac thickness of the two groups were statistically significant (P＜0.05). The multivariate logistic regression analysis found that the larger the value of EAT, PPFT, VFT, PRPFT, VFT/SCFT and right renal fat sac, the higher the risk of CAS, and the difference was statistically significant (P＜0.05), and the difference was still statistically significant after adjusting the multivariate(P＜0.05). ROC curve analysis determined that the AUC values of VFT and PRPFT were 0.943 and 0.843 respectively, which had high sensitivity, and the critical values were 6.25mm and 59.45mm respectively. Conclusion: Visceral fat is related to CAS, while EAT, PPFT, VFT, PRPFT and right kidney fat sac thickness are independent influencing factors of CAS, among which PRPFT and VFT have good diagnostic efficacy.
ZHAO Tianying
,
ZHAO Yazi
,
SHI Zixuan
,
SHEN Qing
,
ZHANG Xia
. A preliminary study of the correlation between ultrasound detection of multi-site visceral fat and atherosclerosis[J]. Journal of Baotou Medical College, 2023
, 39(9)
: 64
-69
.
DOI: 10.16833/j.cnki.jbmc.2023.09.013
[1] Haberka M,Skilton M,Biedron M,et al. Obesity,visceral adiposity and carotid atherosclerosis[J].J Diabetes Complications,2019,33(4): 302-306.
[2] 吴后祎,马领松. NLR预测TIA颈动脉斑块稳定性的可行性研究[J].右江民族医学院学报,2021,43(2): 206-209.
[3] Li Y,Zhao D,Wang M,et al. Association of menopause with risk of carotid artery atherosclerosis[J].Maturitas,2021,143: 171-177.
[4] Neeland IJ,Ross R,Despres JP,et al. International atherosclerosis society; international chair on cardiometabolic risk working group on visceral obesity,visceral and ectopic fat,atherosclerosis,and cardiometabolic disease: a position statement[J].Lancet Diabetes Endocrinol,2019,7(9): 715-725.
[5] Jung CH,Kim BY,Kim KJ,et al. Contribution of subcutaneous abdominal fat on ultrasonography to carotid atherosclerosis in patients with type 2 diabetes mellitus[J].Cardiovasc Diabetol,2014,28(13): 67.
[6] Williams B,Mancia G,Spiering W,et al. 2018 ESC/ESH guidelines for the management of arterial hypertension[J].Eur Heart J,2018,39: 3021-3104.
[7] Rallidis LS,Baroutsi K,Zolindaki M,et al. Visceral adipose tissue is a better predictor of subclinical carotid atherosclerosis compared with waist circumference[J].Ultrasound Med Biol,2014,40(6): 1083-1088.
[8] Roever LS,Resende ES,Diniz AL,et al. Abdominal obesity and association with atherosclerosis risk factors: the Uberlandia Heart Study[J].Medicine (Baltimore),2016,95: 1357.
[9] Hirooka M,Kumagi T,Kurose K,et al. A technique for the measurement of visceral fat by ultrasonography: comparison of measurements by ultrasonography and computed tomography[J].Intern Med,2005,44(8): 794-799.
[10] Parisi V,Petraglia L,Formisano R,et al. Validation of the echocardiographic assessment of epicardial adipose tissue thickness at the rindfleisch fold for the prediction of coronary artery disease[J].Nutr Metab Cardiovasc Dis,2020,30(1): 99-105.
[11] Lear SA,Humphries KH,Kohli S,et al. Visceral adipose tissue,a potential risk factor for carotid atherosclerosis: results of the Multicultural Community Health Assessment Trial (M-CHAT)[J].Stroke,2007,38(9): 2422-9.
[12] Tanaka T,Kishi S,Ninomiya K,et al. Impact of abdominal fat distribution,visceral fat,and subcutaneous fat on coronary plaque scores assessed by 320-row computed tomography coronary angiography[J].Atherosclerosis,2019,287: 155-161.
[13] Erdoğan T,Durakoğlugil ME,Çetin M,et al. Epicardial adipose tissue predicts carotid intima-media thickness independently of body mass index and waist circumference[J].Acta Cardiol Sin,2019,35(1): 32-41.
[14] Iacobellis G,Willens HJ. Echocardiographic epicardial fat: a review of research and clinical applications[J].J Am Soc Echocardiogr,2009,2(12): 1311-9.
[15] Hazem M,Elsamman M,Bazeed S,et al. Noninvasive prediction of carotid artery atherosclerosis by multiple abdominal fat indices measured via ultrasonography[J].Ultrasonography,2021,40(3): 366-377.
[16] De Pergola G,Campobasso N,Nardecchia A,et al. Para- and perirenal ultrasonographic fat thickness is associated with 24-hours mean diastolic blood pressure levels in overweight and obese subjects[J].BMC Cardiovasc Disord,2015,30(15): 108.
[17] Liu BX,Sun W,Kong XQ. Perirenal fat:a unique fat pad and potential target for cardiovascular disease[J].Angiology,2019,70(7): 584-593.
[18] Kim SK,Kim HJ,Hur KY,et al. Visceral fat thickness measured by ultrasonography can estimate not only visceral obesity but also risks of cardiovascular and metabolic diseases[J].Am J Clin Nutr,2004,79(4): 593-9.
[19] Lim S,Quon MJ,Koh KK. Modulation of adiponectin as a potential therapeutic strategy[J].Atherosclerosis,2014,233(2): 721-728.
[20] Nonterah EA,Bots ML,Oduro A,et al. Adiposity phenotypes and subclinical atherosclerosis in adults from sub-saharan africa: an H3africa AWI-Gen study[J].Glob Heart,2021,16(1): 19.
[21] 焦敏,徐凯. CT腹部脂肪定量与颈动脉粥样硬化的相关性研究[J].临床放射学杂志,2022,41(4): 736-740.
[22] Colonetti T,Grande AJ,Amaral MC,et al. Effect of exercise on epicardial adipose tissue in adults: a systematic review and meta-analyses[J].Heart Fail Rev,2021,6(6): 1399-1411.
