Objective: To investigate the related factors of type 2 diabetes mellitus (T2DM) with cerebral vascular disease (CVD) and the risk factors inducing the occurrence of the two diseases. Methods: A total of 218 patients with type 2 diabetes mellitus in our hospital from January 2020 to December 2020 were selected, including 118patients with simple type 2 diabetes mellitus (T2DM group) and 100 patients with type 2 diabetes mellitus complicated with cerebrovascular disease (T2DM+CVD group). The differences of clinical data between the two groups were compared and the data were analyzed by SAS. Results: There were statistically significant differences in age, gender, body mass index (BMI), blood pressure, glycosylated hemoglobin (HbA1c), low density lipoprotein-cholesterol (LDL-C), and cystatin C (CYSC) levels between T2DM group and T2DM+CVD group (P＜0.05), but there was no significant difference in the course of disease, history of tobacco and alcohol, fasting blood glucose (FBG), postprandial 2 h blood glucose (PBG), total cholesterol (TC), triglyceride (TG), and high density lipoprotein-cholesterol (HDL-C) levels between the two groups(P >0.05). Age, sex, BMI, blood pressure, LDL-C, CYSC were positively correlated with the incidence of T2DM and CVD(r ＞0,P＜0.05), while Hb1Ac was negatively correlated with the incidence of T2DM and CVD(r ＜0,P＜0.05). Age and LDL-C might be the risk factors of T2DM with CVD, HbA1c might be the protective factors of T2DM with CVD, while sex, BMI, blood pressure and CYSC might not be independent related factors of T2DM with CVD. Conclusion: Age, sex, BMI, blood pressure, Hb1Ac, LDL-C and CYSC are all related to the incidence of T2DM and CVD. Monitoring the relevant biochemical indexes can actively take intervention measures to prevent T2DM complicated with CVD.
LI Jing
,
WU Yueqin
. Analysis of related factors of type 2 diabetes mellitus complicated with cerebrovascular disease[J]. Journal of Baotou Medical College, 2023
, 39(9)
: 58
-63
.
DOI: 10.16833/j.cnki.jbmc.2023.09.012
[1] Chen L,Magliano DJ,Zimmet PZ.The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives[J].Nat Rev Endocrinol,2011,8(4):228-36.
[2] Henning RJ.Type-2 diabetes mellitus and cardiovascular disease[J].Future Cardiol,2018,14(6):491-509.
[3] 杜宇,付剑亮.糖尿病脑病危险因素及发病机制研究进展[J].国际神经病学经外科学杂志,2016,43(4):358-362.
[4] McBride CL,Akeroyd JM,Ramsey DJ,et al.Statin prescription rates and their facility-level variation in patients with peripheral artery disease and ischemic cerebrovascular disease:insights from the department of veterans affairs[J].Vascular Medicine,2018,23(3):232-240.
[5] 殷鹏,齐金蕾,刘韫宁,等.2005-2017年中国疾病负担研究报告[J].中国循环杂志,2019,34(12):1145-1154.
[6] 施萌婧,臧运华,李媛媛,等.脑血管病与肾脏功能指标关系的研究进展[J].山东医药,2020,60(2):106-108.
[7] Zhang N,Du SM,Ma GS.Current lifestyle factors that increase risk of T2DM in China[J].Eur J Clin Nutr,2017,71(7):832-838.
[8] 中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志,2014,6(7):447-498.
[9] 李福舜.2型糖尿病合并心脑血管病的临床内科观察及治疗[J].全科口腔医学电子杂志,2019,6(13):128.
[10] Zhou R,Dang X,Sprague RS,et al.Alteration of purinergic signaling in diabetes:Focus on vascular function[J].J Mol Cell Cardiol,2020,140:1-9.
[11] 徐成文.2型糖尿病合并心脑血管病危险因素分析及临床疗效观察[J].中国社区医师,2019,35(31):16-19.
[12] Mccrimmon RJ,Ryan CM,Frier BM.Diabetes and cognitive dysfunction[J].Lancet,2012,379(9833):2291-2299.
[13] Van Sloten TT,Sedaghat S,Carnethon MR,et al.Cerebral microvascular complications of type 2 diabetes:stroke,cognitive dysfunction,and depression[J].Lancet Diabetes Endocrinol,2020,8(4):325-336.
[14] Zhou Z,Lingdley RI,Radholm K,et al.Canagliflozin and stroke in type 2 diabetes mellitus[J].Stroke,2019,50(2):396-404.
[15] Assy MH,Awd M,Elshabrawy AM,et al.Effect of Ramadan fasting on incidence of cerebrovascular stroke in Egyptian patients with type 2 diabetes mellitus[J].Diabetes Res Clin Pract,2019,151:299-304.
[16] Wardlaw JM,Smith C,Dichgans M.Small vessel disease:mechanisms and clinical implications[J].Lancet Neurol,2019,18(7):684-96.
[17] Liu J,Rutten-Jacobs L,Liu M,et al.Causal impact of type 2 diabetes mellitus on cerebral small vessel disease:a mendelian randomization analysis[J].Stroke,2018,49(6):1325-31.
[18] Palacio S,McClure LA,Benavente OR,et al.Lacunar strokes in patients with diabetes mellitus:risk factors,infarct location,and prognosis:the secondary prevention of small subcortical strokes study[J].Stroke,2014,45(9):2689-94.
[19] Pan Y,Wang Y,Li H,et al.Association of diabetes and prognosis of minor stroke and its subtypes:a prospective observational study[J].PLoS One,2016,11(4):e0153178.
[20] Hankey GJ,Aaderson NE,Ting RD,et al.Rates and predictors of risk of stroke and its subtypes in diabetes:a prospective observational study[J].J Neurol Neurosurg Psychiatry,2013,84(3):281-7.
[21] Tran H,Anand SS.Oral antiplatelet therapy in cerebrovascular disease,coronary artery disease,and peripheral arterial disease[J].JAMA,2004,292(15):1867-1874.
