Objective: To investigate the relationship between Toll-Like Receptor 3 (TLR3) rs3775290 and the risk of chronic hepatitis B virus infection. Methods: A total of 172 patients with chronic hepatitis B were selected as the CHB case group and 200 healthy people as the control group in Ordos, Inner Mongolia. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) was used to detect the gene polymorphism of TLR3 rs3775290 in the CHB case group and the control group. The odds ratio (OR) and its 95 % confidence interval (CI) were calculated by non-conditional Logistic regression to assess the relationship between alleles,genotypes and the risk of chronic hepatitis B infection. Results: Frequencies of SNP rs3775290 on GG, AG and AG genotypes in the control group were 50.5 %, 39.5 % and 10.0 % respectively, while the frequencies in the CHB case group were 56.4 %, 34.9 % and 8.7 % respectively. There was no significant difference between the two groups (P＞0.05). SNP rs3775290 was not associated with the risk of chronic HBV infection under codominant genetic model , dominant genetic model, recessive genetic model and super dominant genetic model (P＞0.05). Conclusion: TLR3 rs3775290 has no relationship with the risk of chronic hepatitis B virus infection in Han population in Ordos, Inner Mongolia.
DONG Wenjie
,
YAN Xiaoxia
,
JIA Yanbin
,
XIE Yingbo
,
GaoFang
. Association of TLR3 rs3775290 and chronic hepatitis B virus infection[J]. Journal of Baotou Medical College, 2023
, 39(9)
: 8
-11
.
DOI: 10.16833/j.cnki.jbmc.2023.09.002
[1] Hutin Y, Bulterys M. Prevention of mother-to-child transmission of hepatitis B virus: guidelines on antiviral prophylaxis in pregnancy[M].Geneva: World Health Organization, 2020: 17-18.
[2] 张书彦. 乙型肝炎病毒流行现状及病毒基因型研究[J].中国卫生工程学, 2020, 19(4): 531-533.
[3] 王晓军, 张荣珍, 胡苑笙, 等. 我国病毒性肝炎流行现状研究[J].疾病监测, 2004, 19(8): 290-292.
[4] 葛大赫. 慢性乙型肝炎及肝硬化、肝癌患者外周血Th1、Th2类细胞因子表达变化及意义[J].中国卫生工程学, 2022, 21(1): 160-162.
[5] 樊捷, 倪猛. 慢性乙型肝炎患者焦虑状况及其影响因素[J].中国卫生工程学, 2022, 21(1): 93-95.
[6] 段朝霞. Toll样受体家族与天然免疫[J].国外医学(分子生物学分册), 2002, 24(6): 380-383.
[7] 魏巴金. Toll样受体家族基因多态性与肝移植后乙肝复发的关系[D].浙江大学, 2011.
[8] 许聪, 乔亚丽, 张道来. Toll样受体家族成员在人肝细胞癌中的表达及其与炎性体因子的相关性[J].细胞与分子免疫学杂志, 2017, 33(9): 1182-1186.
[9] 黄霞梅. Toll样受体基因多态性与HBV相关性肝炎、肝硬化、肝癌的遗传易感性研究[D].广西医科大学, 2013.
[10] Matsumoto M, Oshiumi H, Seya T. Antiviral responses induced by the TLR3 pathway[J].Rev Med Virol, 2011, 21(2): 67-77.
[11] 王红梅, 李永哲, 赵冠飞, 等. 原发性胆汁性肝硬化患者外周血单个核细胞中Toll样受3 mRNA表达水平的研究[J].中华风湿病学杂志, 2008, 12(11): 762-765.
[12] Al-Qahtani A, Al-Ahdal M, Abdo A, et al. Toll-like receptor 3 polymorphism and its association with hepatitis B virus infection in Saudi Arabian patients[J].J Med Virol, 2012, 84(9): 1353-1359.
