Objective: To study the effect of applying hydrocolloid dressing joint colostomy products to the protection of surrounding skin in intestinal fistula patients.Methods: 50 cases of patients with intestinal fistula hospitalized in gastrointestinal surgery from January 2014 to October 2016 were selected and randomly divided into experimental group and control group, 25 cases in each group. The experimental group was treated with hydrocolloid dressing joint colostomy products, while the control group was treated with traditional continuous washing plus pressure suction and zinc oxide coating to protect the skin.Results: In terms of objective indicators, the dermatitis incidence and severity of the fistula surrounding skin in experimental group were significantly lower than those in control group (P＜0.05); the average daily dressing change was significantly less than that in control group (P＜0.05). The subjective assessment of indicators in the Nottingham health scale (NHP) in experimental group was superior to that in control group (P＜0.05).Conclusion: Hydrocolloid dressings joint colostomy products can protect fistula surrounding skin, effectively prevent pollution of liquid leakage to abdominal incision and stimulation of liquid leakage to the surrounding skin, accelerate the fistula healing, ease the family economic burden, and at the same time reduce the workload of medical staff, which is worthy of promotion.