Objective: To observe the changes of serum heparanase levels in patients with acute decompensated chronic heart failure before and after treatment, and to study the correlation between the efficacy and changes in serum HPSE levels in patients with chronic heart failure. Methods: Fifty hospitalized patients with ADHF were selected and included in the treatment group, 30 patients with underlying heart disease but not yet reaching the level of heart failure who were hospitalized during the same period served as the experimental control group, and 30 healthy individuals who underwent physical examination during the same period were included in the normal control group. The changes of serum HPSE in patients with heart failure before and after treatment were detected by ELISA, and the relationship between NT-proBNP and serum heparanase in the treatment group before and after treatment and in the control group was observed. Results: After heart failure treatment, the levels of HPSE and NT-proBNP were significantly lower than those before treatment, and the difference was statistically significant (P＜0.05). The level of serum HPSE before treatment was higher than that of the experimental and normal control groups, and the serum HPSE after treatment was higher than that of the normal control group. There was no significant difference with the experimental control group (P＞0.05). Pearson correlation analysis indicated that blood HPSE and NT-proBNP levels were positively correlated before and after treatment. Conclusion: Serum HPSE levels were significantly higher in patients with ADHF, and the index decreased significantly after correction of heart failure, and was positively correlated with NT-proBNP levels; serum HPSE levels may be correlated with the severity of heart failure.
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