Objective: To investigate the diagnostic value of neutrophil/high-density lipoprotein cholesterol ratio (NHR) combined with platelet/lymphocyte ratio (PLR) in valvular calcification in elderly patients with degenerative heart valvular disease (SDHVD). Methods: A total of 229 patients with cardiac valve calcification treated from November 2019 to November 2021 were selected as the experimental group, and 229 patients with non-cardiac valve calcification with normal echocardiographic results during the same period were selected as the control group. Blood routine analyzer and biochemical analyzer were used to detect the indexes of the two groups of patients, and the NHR, PLR, NHR and PLR were calculated. Application of receiver operating characteristic curve (ROC) was to evaluate the value of NHR combined with PLR in the auxiliary diagnosis of valve calcification in SDHVD. Results: The white blood cell count in the experimental group was 6.21 (5.25～7.99)×109/L, which was higher than that in the control group, which was 5.83(4.54～7.25)×109/L (P=0.003). The neutrophil count in the experimental group was 4.25(3.19～5.54)×109/L, which was higher than that in the experimental group, which was 3.52 (2.70～4.79) × 109/L (P＜0.001). The platelet count in the experimental group was 195.50 (152.50～232.50)×109/L, which was higher than that in the control group, which was 175.00(138.00～213.00)×109/L, (P=0.001). The high density lipoprotein cholesterol of 1.21 (0.98 ~ 1.49) ×mmol/L in the control group was higher than that of 1.11 (0.92 ~ 1.34) ×mmol/L in the experimental group (P＜0.05). NHR 3.74 (2.55 ~ 5.69) in the experimental group was higher than 3.07 (2.13 ~ 4.29) in the control group (P＜0.001). PLR in the experimental group was 147.13 (107.99-196.54) higher than that in the control group (125.00 (97.88-161.21) (P＜0.001). ROC curve results showed that when 4.56 was taken as the threshold of NHR and the area under the curve was 0.627, the sensitivity and specificity of diagnosing SDHVD valve calcification were 38.90 % and 81.70 %, respectively. Using 138.98 as the PLR threshold, the area under the curve was 0.624, and the sensitivity and specificity for the diagnosis of SDHVD valve calcification were 57.60 % and 60.30 %, respectively. Combined with NHR and PLR in the diagnosis of SDHVD valve calcification, the optimal cut-off value was 280.66, the area under the curve was 0.681, and the sensitivity and specificity were 58.10 % and 65.10 %, respectively. Conclusion: There are changes in NHR and PLR in patients with SDHVD valve calcification. NHR combined with PLR can be used as an auxiliary diagnostic indicator for SDHVD valve calcification.
HUANG Hongtao
,
CHEN Lin
,
WANG Huixuan
,
JU Linling
,
WU Jing
,
GONG Yachi
. Diagnostic value of NHR combined with PLR for valve calcification in elderly patients with degenerative heart valve disease[J]. Journal of Baotou Medical College, 2023
, 39(8)
: 28
-32
.
DOI: 10.16833/j.cnki.jbmc.2023.08.006
[1] 齐喜玲,许海燕,刘庆荣,等. 中国老年退行性心脏瓣膜病住院患者诊疗现状分析[J]. 中国循环杂志,2019,34(8):771-776.
[2] 赵萍,潘闽,龚亚驰,等. 南通地区老年退行性心脏瓣膜病的危险因素[J]. 中国老年学杂志,2019,39(18):4385-4388.
[3] Passos L S A,Lupieri A,Becker-Greene D,et al. Innate and adaptive immunity in cardiovascular calcification[J].Atherosclerosis,2020,306:59-67.
[4] KouT,Luo H,Yin L. Relationship between neutrophils to HDL-C ratio and severity of coronary stenosis[J].BMC Cardiovasc Disord,2021,21(1):127.
[5] Huang JB,ChenYS,JiHY,et al. Neutrophil to high-density lipoprotein ratio has a superior prognostic value in elderly patients with acute myocardial infarction:a comparison study[J].Lipids Health Dis,2020,19(1):59.
[6] Arbel Y,Finkelstein A,Halkin A,et al. Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography[J].Atherosclerosis,2012,225(2):456-460.
[7] Van Engeland NCA,Bertazzo S,Sarathchandra P,et al. Aortic calcified particles modulate valvular endothelial and interstitialcells[J].CardiovascPathol,2017,28:36-45.
[8] Brescia AA,Paulsen MJ,Watt TMF,et al. Economic analysis and long-term follow-up of distant referral for degenerative mitral valve repair[J].Ann Thorac Surg 111, 479-486 (2021).
[9] Weiss RM,Miller JD,Heistad DD. Fibrocalcific aortic valve disease [J]. Circulation Research,2013,113(2):209-222.
[10] Nikolsky E,Grines CL,Cox DA,et al. Impact of baseline platelet count in patients undergoing primary percutaneous coronary inter-vention in acute myocardial infarction(from the CADILLAC trial)[J].Am J Cardiol,2007,99(8):1055-1061.
[11] Balta S, Celik T, Mikhailidis DP,et al. The relation between atherosclerosis and the neutrophil-lymphocyte ratio[J].Clin Appl Thromb Hemost,2016,22(5):405-411.
