Objective: To investigate the effect of antibiotics on the prognosis of first-line platinum-based chemotherapy in patients with non-small cell lung cancer (NSCLC). Methods: A total of 125 patients with advanced NSCLC who received first-line platinum-based two-drug chemotherapy were retrospectively included, and those who used antibiotics during chemotherapy were the antibiotics group and those who did not were the control group.The efficacy and adverse effects of patients were evaluated by comparing the examination reports after 2 cycles of chemotherapy with those at baseline.Clinical endpoints were objective effectiveness rate (ORR) and disease control rate (DCR), and adverse reactions included hematologic adverse reactions (leukopenia, granulocytopenia, thrombocytopenia, hemoglobin reduction) and gastrointestinal adverse reactions. Results: The ORR in the antibiotics group (8.3 %) was significantly lower than that in the control group (20.8 %) (P=0.045).The DCR in the antibiotics group (77.8 %) was lower than that in the control group (90.6 %), but there was no statistical difference (P=0.059).There was no significant difference in the hematologic adverse events including leukopenia, granulocytopenia, thrombocytopenia, and hemoglobin reduction between the two groups (P＞0.05).In contrast, there was a significant difference in gastrointestinal adverse reactions (P=0.036), with 50 cases (69.4 %) in the antibiotics group and 27 cases (50.9 %) in the control group. Conclusion: Antibiotics can affect the prognosis of patients with advanced NSCLC treated with first-line chemotherapy and should be given to cancer patients under strict indications.
GAO Jianjun
,
FAN Xiuru
,
WANG Gang
,
BAI Yingchun
,
GUO Xiaobin
. Prognosis of antibiotics on first-line platinum-based chemotherapy for non-small cell lung cancer[J]. Journal of Baotou Medical College, 2023
, 39(8)
: 12
-16
.
DOI: 10.16833/j.cnki.jbmc.2023.08.003
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