Objective: To explore the application effect of the Mobile Internet & Unified-Diabetes-Care model in the home management of diabetes.Methods: A total of 892 patients with type 2 diabetes who received medical treatment from March 2020 to October 2021 were selected for whole-process management by the Unified-Diabetes-Care team relying on the mobile terminal of the Internet blood glucose management platform.The questionnaire on cognition and behavior of diabetes-related knowledge and the self-management ability survey scale were used for collection and evaluation before and 6 and 12 months after management, respectively.At the same time, the changes of fasting blood glucose, blood glucose 2 hours after meals, glycosylated hemoglobin, blood lipid, urinary albumin/creatinine and other metabolic indexes before and after management were compared.Results: After 6 months and 12 months of management, the cognition and behavior of diabetes-related knowledge were improved compared with that before management, and increased with the extension of management time (P＜0.05).Diet control, regular exercise, medication compliance, blood glucose detection, complication management and scale total score were improved (P＜0.05), and the diet control, regular exercise and complication management were further improved after 12 months compared with 6 months of management (P＜0.05).The up-to-standard rates of blood glucose and blood pressure were significantly increased after management, and further increased with the passage of time (P＜0.05).Fasting blood glucose, 2 hours postprandial blood glucose, glycosylated hemoglobin, blood lipid, urinary albumin/creatinine were significantly decreased after management (P＜0.05), and fasting blood glucose, glycosylated hemoglobin, urinary albumin/creatinine were continuously improved after 12 months of management compared with 6 months of management (P＜0.05).Conclusion: Home management of type 2 diabetes patients through the Mobile Internet & Unified-Diabetes-Care model has continuously enhanced the self-management awareness and management behavior of patients, improved the metabolic indicators such as blood sugar, blood fat, urinary albumin/creatinine, and increased the standard compliance rate.The application of the new management model has greatly improved the level of chronic disease management.