Epidemiological characteristics and drug resistance analysis of central nervous system infections in elderly populations from 2014 to 2021

WANG Xingyu; MA Licong; CHANG Yanqin; GAO Hongbo; ZHANG Jing

doi:10.16833/j.cnki.jbmc.2023.06.015

2023 , Vol. 39 >Issue 6: 72 - 77

DOI: https://doi.org/10.16833/j.cnki.jbmc.2023.06.015

Epidemiological characteristics and drug resistance analysis of central nervous system infections in elderly populations from 2014 to 2021

WANG Xingyu ,
MA Licong ,
CHANG Yanqin ,
GAO Hongbo ,
ZHANG Jing

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1. School of Basic Medicine and Forensic Medicine, Baotou Medical College, Baotou 014040, China;
2. Department of Pathology, The Second Affiliated Hospital of Baotou Medical College;
3. Department of Laboratory Medicine, Baotou Central Hospital

Received date: 2022-12-18

Online published: 2023-06-30

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Abstract

Objective: To investigate the epidemic characteristics of pathogens, drug sensitivity and drug resistance in middle-aged and elderly patients with central nervous system infection (CNSI). Methods: A total of 105 middle-aged and elderly patients with cerebrospinal fluid (CSF) culture positive from 2014 to 2021 were collected for microbial identification and drug sensitivity study. Pheonix100 system was used to identify the isolated pathogens, and K-B (disk diffusion) method was used to determine the antibacterial sensitivity of the isolates. Results: Among the isolates, Gram-positive and Gram-negative bacteria accounted for 69.52 % and 30.48 %, respectively. Epidemiological investigation showed that cerebrospinal fluid positive patients in different ages had significant differences (P＜0.05). Staphylococcus epidermidis content was the highest in patients 45-60 years old. In patients 60 and more than 60 years old, the infection rate of Acinetobacter baumannii (25.0 %) was the highest. The sensitive rates of Staphylococcus strains to linezolid and vancomycin were 100 %. Acinetobacter baumannii was more sensitive to cefoperazone/sulbactam and polymyxin B. Klebsiella pneumoniae was more sensitive to imipenem and meropenem. Conclusion: The clinical selection of antibiotics can be based on the resistance characteristics of different bacteria.

Key words： Elderly population; Cerebrospinal fluid; Bacterial culture; Drug resistance; Epidemiological characteristics

Cite this article

WANG Xingyu , MA Licong , CHANG Yanqin , GAO Hongbo , ZHANG Jing . Epidemiological characteristics and drug resistance analysis of central nervous system infections in elderly populations from 2014 to 2021[J]. Journal of Baotou Medical College, 2023 , 39(6) : 72 -77 . DOI: 10.16833/j.cnki.jbmc.2023.06.015

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