Objective: To investigate the short-term effect and possible mechanism of paclitaxel in local vascular delivery of autogenous arteriovenous fistula(AVF). Methods: Thirty-six white rabbits were randomly divided into observation group and control group. After the completion of the animal model, AVF vessels in each group were surgically removed at 2 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks and 12 weeks, and the morphological changes of venous vessels were observed by HE staining. The expressions of Beclin-1, LC3Ⅱ and PDGF-bb in venous wall were observed by immunohistochemistry. Results: The intima venous thickness in the observation group was lower than that in the control group (P＜0.05), and the expression of Beclin-1, LC3Ⅱ and PDGF-bb in the observation group was slightly lower than that in the control group, with no statistical significance (P＞0.05). Conclusion: Local delivery of paclitaxel to autologous AVF can reduce the abnormal hyperplasia of the venous intima. It provides a new therapeutic idea for AVF stenosis.
ZHOU Zhiyong
,
LI Ying
,
ZHAO Shengyan
,
BAO Hongjing
. Study on pathological changes of paclitaxel in local vascular delivery site of autogenous arteriovenous fistula[J]. Journal of Baotou Medical College, 2023
, 39(6)
: 20
-23
.
DOI: 10.16833/j.cnki.jbmc.2023.06.005
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