Objective: To systematically review the toxoplasma infection rate and risk factors among pregnant women in mainland China, so as to provide references for prevention strategies.Methods: The original study on the toxoplasma infection rate and risk factors in pregnant women in China were searched in databases as PubMed, CNKI, VIP and Wan Fang. 18 published studies were finally included according to the inclusion and exclusion criteria, and Meta Analyst Beta 3.13 software and Rev Man 5.2 software were adopted to make the Meta-analysis.Results: The results showed that the toxoplasma infection rate was 8.10% (95 % CI: 6.80 %-9.70 %) in Chinese pregnant woman. The combined exposure relative risk (RR) and 95% CI of bad eating habits, animal contact, abnormal gestation, village (suburb) and senile gravida were 1.43 (1.22,1.68), 2.96 (1.95,4.49), 5.52 (3.65,8.37), 1.37 (1.20,1.57) and 1.31 (1.05,1.64) respectively.Conclusion: Toxoplasma infection rate among pregnant women in mainland China is higher, poor eating habits, animal contact, abnormal gestation, village (suburb) and senile gravida are toxoplasma infection risk factors among pregnant women. The changeable risk factors should be targeted to the pregnant women for early intervention.
[1] Li F,Wang S P,Wang C J, et al. Seroprevalence of Toxoplasma gondii in goats in Hunan province,China[J]. Parasite, 2016; 23: 44.
[2] Zhou P, Chen N, Zhang RL, et al. Food-borne parasitic zoonoses in China:Perse-ctive for control[J].Trends Parasitol, 2008;24(4):190-196.
[3] Gao XJ, Zhao ZJ, He ZH, et al.Toxoplasma gondii infection in pregnant women in China[J]. Parasitology. 2012 ;139(2):139-147.
[4] 周佼佼,陶莉莉.无锡地区孕妇弓形虫感染及危险因素调查[J].中国血吸虫病防治杂志, 2015,06:604-607.
[5] 翟振武,张现苓,靳永爱.立即全面放开二胎政策的人口学后果分析[J].人口研究, 2014,38(02):3-17.
[6] Stroup DF,Berlin JA,Morton SC, et al. Meta-analysis of observationl studies in epidemiology:aproposal for reporting. Meta-analysis of obser vational studies in Epidemiology(MOOSE)group[J]. JAMA. 2000 Apr 19;283(15):2008-2012.
[7] Loney PL,Chambers LW,Bennett KJ, et al. Critical appraisal of the health research literature:prevalence or incidence of a health problem[J]. Chronic Discan, 1998,19(4):170-176.
[8] Wallace BC,Schmid CH,Lauj, et al. Meta-Anaiyst:sofeware for meta-anaiysis of binry,continuous and diagnostic data[J]. BMC Methodol, 2009,9(1):80-91.
[9] 仝德胜,华海涌,陈伟,等.拉萨市部分地区孕妇弓形虫感染现状调查及危险因素探讨[J].中国血吸虫病防治杂志, 2016,(6):708-710.
[10] 杨文丽,王英.河北省廊坊市育龄期妇女与孕妇弓形虫感染状况调查[J].中国血吸虫病防治杂志, 2016,(2):210-211.
[11] 王英,杨文丽.河北省霸州市孕妇弓形虫感染及其知晓度的相关性调查[J].中国血吸虫病防治杂志, 2016,(3):340-342.
[12] 侯丽萍,张慧芳,饶华祥,等.太原市孕妇弓形虫感染现况调查[J].中国病原生物学杂志, 2015,(1):100-101.
[13] Cong W, Dong XY, Meng QF, et al.Toxoplasma gondii Infection in Pregnant Women:A Seroprevalence and Case-Control Study in Eastern China. Biomed Res Int[J]. 2015: 170278.
[14] 张慧芳,侯玉英,杨晓丽,等.太原市部分孕妇感染弓形虫状况的调查与分析[J].中国药物与临床, 2014,(10):1367-1368.
[15] 陈玉昆,杨亚晓,魏世锦,等.孕早期妇女弓形虫感染对妊娠结局的影响[J].中国血吸虫病防治杂志, 2014,(3):308-310.
[16] 辛克盛,潘敏,刘慧,等.青岛地区孕妇弓形虫感染调查[J].中国血吸虫病防治杂志, 2014,(3):320-322.
[17] 赵聪伟.安国市孕妇弓形虫感染状况及其对妊娠结局的影响[J].热带医学杂志, 2014,(8):1057-1059.
[18] 张燕萍,宋任浩.孕妇弓形虫感染妊娠结局及危险因素调查[J].中国血吸虫病防治杂志, 2014,(2):221-223.
[19] 秦永超,岳红霞,王彬,等.长春地区孕妇感染弓形虫株的基因分型[J].中国病原生物学杂志, 2013,(9):790-792+814.
[20] 华海涌,唐凤,刘一新,等.江苏省孕妇弓形虫感染情况调查[J].中国血吸虫病防治杂志, 2013,(1):56-58+79.
[21] 李建名.安徽省淮南地区部分孕产妇TORCH感染检测分析[J].安徽卫生职业技术学院学报, 2012,(1):107-108.
[22] 何桂儿,曾华,王晶晶,等.孕妇血清中抗弓形虫抗体IgG和IgM检测分析[J].临床医学工程, 2012,(6):956-957.
[23] 刘长生.异常妊娠史孕妇弓形虫感染情况调查[J].中国病原生物学杂志, 2011,(9):718+660.
[24] 王金英.邢台市区及郊区孕妇弓形体感染情况调查分析[J].临床合理用药杂志, 2011,(3):124-125.
[25] 夏薇,张小俊,陈锡慰.南京地区孕妇弓形虫感染不同妊娠结局研究[J].中国血吸虫病防治杂志, 2011,(2):183-186.
[26] 张欠欠,成俊珍,王逢会.延安市孕妇TOX-IgM检测结果分析[J].中国热带医学, 2012,(12):1469-1471.
[27] 王金英.邢台市区及郊区孕妇弓形体感染情况调查分析[J].临床合理用药杂志, 2011,(3):124-125.
[28] 张婷,罗亮,许飞,等. 2461例孕妇TORCH感染情况及相关因素的调查研究[J].中华医院感染学杂志, 2011,(11):2250-2252.
[29] 吴希静,朱前,胡春秀,等.铜陵地区2845例孕妇TORCH感染状况分析[J].检验医学与临床, 2013,(13):1658-1659+1661.
[30] 张欠欠,成俊珍,王逢会.延安市2850例孕妇弓形虫感染情况调查[J].中国病原生物学杂志, 2013,03:292-293.
[31] 康栗.安徽淮南地区孕妇弓形虫感染情况调查[J].热带病与寄生虫学,2015,02:108-109.
[32] 杨娟,郑青山. Meta分析的统计学方法[J].中国临床药理学与治疗学, 2005,11:1309-1314.
[33] 魏海霞,李雪兰,张浩,等.孕妇弓形虫感染相关诱因的Meta分析[J].中国人兽共患病学报, 2013,(12):1177-1180.
[34] 姚天一,张志坤.弓形虫感染与围生儿预后[J].中国实用妇科与产科杂志, 2005,(6):339-341.
[35] Jones jl,dargelasv,robertsj,et al. Risk factors for Toxo-plasma gondii infection in the united states. Clin infect Dis, 2009,49(6):878-884.
[36] 郭燕丽,邹永根,许大成,等. 江苏省常州市特殊人群弓形虫感染调查及影响因素分析[J]. 中国血吸虫病防治杂志, 2016,(6):669-673,698.