Objective: To investigate the correlation between coagulation related indexes and the degree of liver function impairment and occurrence of ascites in patients with liver cirrhosis. Methods: Clinical data of 92 cirrhotic patients from treated in the Department of Gastroenterology of the First Affiliated Hospital of Baotou Medical College from August 2020 to April 2022 were collected and grouped according to the Child-Pugh classification, MELD score and presence of ascites. Coagulation related indexes were detected, including prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen (FIB), prothrombin activity (PTA) and international normalized ratio (INR). Results: PT, APTT, TT and INR were lower in the healthy control group, low-MELD group and cirrhosis without ascites group than that in the cirrhosis group, high-MELD group and cirrhosis with ascites group (P<0.05), while PTA and FIB were higher than those in the cirrhosis group, high-MELD group and cirrhosis with ascites group (P< 0.05). PT, APTT, TT, INR in the Child A and B groups were lower than those in the Child C group, while PTA and FIB were higher than those in the Child C group (P<0.05), and the differences of PT, PTA, APTT, TT, FIB and INR between Child A and B groups were statistically significant (P< 0.05). Conclusion: Coagulation related indexes are closely related to the degree of hepatic impairment in patients with cirrhosis, and of certain value in predicting ascites.
WANG Binbin
,
LIU Yueqing
,
WANG Peng
. Correlation study between coagulation indexes and liver function grading in patients with liver cirrhosis[J]. Journal of Baotou Medical College, 2023
, 39(5)
: 51
-54
.
DOI: 10.16833/j.cnki.jbmc.2023.05.010
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