Objective: To investigate the expression of serum platelet activating factor (PAF), carcinoembryonic antigen (CEA) and carbohydrate antigen 724 (CA-724) in patients with colorectal cancer (CRC), and the correlation between PAF and CEA and CA-724, so as to provide reference for the subsequent diagnosis of CRC patients. Methods: A total of 75 CRC patients who visited the First Affiliated Hospital of Baotou Medical College from December 2019 to October 2021 were collected, and 75 healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group. ELISA method was used to detect the PAF levels in the morning fasting peripheral venous blood of CRC patients before surgery, 1 month after surgery, and the control group. The preoperative serum levels of CEA and CA-724 in the above two groups of patients were retrospectively analyzed, and statistical analysis was performed. Results: The levels of serum PAF, CEA and CA-724 in CRC group before operation were significantly higher than those in the control group (P<0.05). The PAF content of CRC patients at different stages was higher than that of the control group, in which the content of stage I and stage Ⅱ was significantly increased, and the content of stage Ⅲ and stage IV was decreased compared with that of stage I and stage Ⅱ; there were significant differences between stage I, stage Ⅱ and stage Ⅲ and the control group and stage Ⅳ (P<0.05). The contents of CEA and CA-724 gradually increased with the increase of TNM stage, and there were significant differences between each group except I and Ⅱ (P<0.05 ). PAF was negatively correlated with CEA and CA-724 (P<0.05). The PAF level in CRC group at 1 month after operation was significantly lower than that before operation (P<0.05). Conclusion: Serum PAF is highly expressed in CRC, and surgery can reduce its content, which is negatively correlated with CEA and CA-724. PAF is expected to become an important reference index for early CRC screening.
YAN Shuzhen
,
WANG Zhanlong
,
WU Wenchun
,
HUANG Yandong
,
FENG Kai
. Expression and clinical significance of platelet activating factor in colorectal cancer[J]. Journal of Baotou Medical College, 2023
, 39(5)
: 38
-42
.
DOI: 10.16833/j.cnki.jbmc.2023.05.008
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