Objective: To investigate the relationship between SNP rs2072493 in Toll-like receptor 5 (TLR5) gene and genetic susceptibility to primary liver cancer. Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect the genotype distributions of SNP rs2072493 in 205 patients with primary liver cancer and 238 normal people. The odds ratio (OR) and 95 % confidence interval (CI) were calculated by non-conditional logistic regression to evaluate the relationship between rs2072493 and the risk of primary liver cancer under the four genetic models of Codominant, Dominant, Recessive and Overdominant. Results: SNP rs2072493 was associated with the risk of primary liver cancer under Codominant, Dominant and Recessive genetic models. The codominant genetic model was the best model with the lowest AIC and BIC value. Compared with AA genotype, GA and GG genotype could reduce the risk of primary liver cancer (GA vs AA: OR=0.512, 95 % CI=0.333-0.787; GG vs AA: OR=0.192, 95 % CI=0.077-0.477). Conclusion: SNP rs2072493 in TLR5 is associated with the risk of primary liver cancer.
QIN Jindong
,
GAO Fang
,
LI Yingze
,
LI Peng
,
JIA Yanbin
. Relationship between SNP rs2072493 in TLR5 and susceptibility to primary liver cancer[J]. Journal of Baotou Medical College, 2023
, 39(5)
: 6
-9
.
DOI: 10.16833/j.cnki.jbmc.2023.05.002
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