Electrophysiological characteristics on POEMS Syndrome

  • YUE Yayan ,
  • YU Ming
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  • Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China

Received date: 2022-10-19

  Online published: 2023-03-08

Abstract

Objective: To analyze the characteristics of electromyography (EMG) in POEMS syndrome and provide a reference for the disease identification. Methods: The EMG of 8 patients with POEMS syndrome in our hospital (patient group) has been analyzed in detail. The extraction rate of compound muscle action potential(CMAP), sensory nerve action potential(SNAP) and F-wave of upper and lower limbs has been compared. The CMAP and SNAP amplitude (AMP), motor nerve conduction velocity (MCV), sensory nerve conduction velocity (SCV), distal motor latency (DML), the F-wave latency of median nerve and tibial nerve, the terminal latency index (TLI) of median and ulnar nerve, and the needle pole electromyography (EMG) has been statistically analyzed with the healthy control group as a reference. Results: In the patient group,the appearance of SNAP was lower than that of CMAP (P<0.05), the appearance of CMAP and SNAP was apparently higher in the upper limb than in the lower limb(P<0.05), The F-wave extraction rate of median nerve (100 %) was higher than that of tibial nerve (0 %). In comparison with the control group , the DML was prolonged, the CMAP and SNAP amplitude was decreased, the MCV and SCV was slowed down, the F-wave extraction rate of tibial nerve was decreased, and the latency of median nerve F-wave was longer in the patient group (P<0.05). The ulnar nerve terminal latency index (TLI) in the patients group was significantly higher than that in the normal group (P<0.05). The abnormal rate of needle electromyography was 24.14 % in the patient group, and the abnormal rate of anterior tibial muscle was the highest (50 %). Conclusion: Motor nerve and sensory nerve conduction are all abnormal in POEMS patients, F-wave abnormal rate is high, electromyography may appear neurogenic damage, tibialis anterior muscle was the most commonly involved.

Cite this article

YUE Yayan , YU Ming . Electrophysiological characteristics on POEMS Syndrome[J]. Journal of Baotou Medical College, 2023 , 39(3) : 37 -41 . DOI: 10.16833/j.cnki.jbmc.2023.03.008

References

[1] Suichi T, Misawa S, Beppu M, et al. Prevalence, clinical profiles, and prognosis of POEMS syndrome in Japanese nationwide survey[J].Neurology, 2019,93(10): e975-e983.
[2] Yu Ri Kim. Update on the POEMS syndrome[J].Blood Res, 2022,57(S1): 27-31.
[3] Dispenzieri A. POEMS syndrome: 2017 update on diagnosis, risk stratification, and management[J].Am J Hematol, 2017,92(8): 814-829.
[4] Keddie S, Foldes D, Caimari F, et al. Clinical characteristics, risk factors, and outcomes of POEMS syndrome: a longitudinal cohort study[J].Neurology, 2020,95(3): e268-e279.
[5] 管宇宙, 崔丽英, 蒲传强. 中国POEMS综合征周围神经病变诊治专家共识[J].中华神经科杂志, 2019,52(11): 893-897.
[6] 王萌, 张靖岚, 万鼎铭, 等.POEMS综合征患者的临床特征及疗效分析[J].中国实验血液学杂志, 2021,29(05): 1645-1648.
[7] Piccione EA, Engelstad J, Dyck PJ, et al. Nerve pathologic features differentiate POEMS syndrome from CIDP[J].Acta Neuropathol Commun, 2016,4(1): 1-7.
[8] Li J, Zhou DB, Huang Z, et al. Clinical characteristics and long-term outcome of patients with POEMS syndrome in China[J].Ann Hematol, 2011,90(7): 819-826.
[9] Yang S, You R, Diao S, et al. The genetic and neuropathological features of POEMS syndrome: a case report[J].Rev Neurol, 2022,178(3): 275-278.
[10] Liu M, Zou Z, Guan Y, et al. Motor nerve conduction study and muscle strength in newly diagnosed POEMS syndrome[J].Muscle Nerve, 2015,51(1): 19-23.
[11] Min JH, Lee DK, Lee S, et al. POEMS syndrome presenting with acute demyelinating polyneuropathy: increased terminal latency indices and uniform demyelination[J].Internal Medicine, 2013,52(13): 1513-1516.
[12] Ding QY, Li J, Guan YZ, et al. Nerve ultrasound studies in Poems syndrome[J].Muscle nerve, 2021,63(5): 758-764.
[13] Mauermann ML, Sorenson EJ, Dispenzieri A, et a1.Uniform demyelination and more severe axonal loss distinguish POEMS syndrome from CIDP[J].J Neurol Neurosurg Psychiatry, 2012,83(5): 480-486.
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