Objective: To investigate the diagnostic value of combined detection of tumor markers ProGRP, CEA, CYFRA21-1, NSE and SCC in the diagnosis of benign and malignant pleural effusion.Methods: A total of 131 cases of pleural effusion diagnosed as benign pleural effusion and malignant pleural effusion in the First Affiliated Hospital of Baotou Medical College from January 2020 to January 2021 were collected, including 87 cases of BPE and 44 cases of MPE. The concentrations of ProGRP, CEA, CYFRA21-1, NSE and SCC in pleural effusion of patients were detected by chemiluminescence method, and the levels of tumor markers in benign and malignant pleural effusion were compared. Five tumor markers were combined in different ways, and the diagnostic values of different combinations were compared by receiver operating characteristic (ROC) curve analysis. Results: The area under the ROC curve (AUC) corresponding to the combination of ProGRP+CEA+CYFRA21-1+NSE was the largest (0.841), and the sensitivity was 77.3 %, the specificity was 85.1 %, the positive likelihood ratio was 5.188, and the negative likelihood ratio was 0.267, with the highest diagnostic value. Conclusion: The combination of ProGRP+CEA+CYFRA21-1+NSE is superior to other combinations in terms of diagnostic efficacy, specificity, sensitivity, positive likelihood ratio and negative likelihood ratio, and has important reference value in the differential diagnosis of pleural effusion.
LI Yanming
,
WANG Cuifeng
,
REN Meiying
. Diagnostic value of combined detection of tumor markers for benign and malignant pleural effusion[J]. Journal of Baotou Medical College, 2023
, 39(2)
: 36
-40
.
DOI: 10.16833/j.cnki.jbmc.2023.02.007
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